干眼患者临床特征的多中心研究  

Clinical characteristics of dry eye outpatients in China:a multicenter study

作　　者：任杰 刘畅[1,2] 周奇志 曾庆延 李玲 窦泽夏[1,2] 王丛香 陈铁红 鲁静 晏艳霜[9,10] 牛晓霞[11] 孙旭光[1,2,12] 李绍伟 Ren Jie;Liu Chang;Zhou Qizhi;Zeng Qingyan;Li Ling;Dou Zexia;Wang Congxiang;Chen Tiehong;Lu Jing;Yan Yanshuang;Niu Xiaoxia;Sun Xuguang;Li Shaowei(Beijing Aier Intech Eye Hospital,Bejing 100021,China;Aier Corneal Institute,Beijing 100021,China;Department of Ophthalmology,Beijing Luhe Hospital,Capital Medical University,Beijing 101149,China;Chonging Optometry Ophthalmic Hospital,Chongqing 400000,China;Hankou Aier Eye Hospital,Wuhan 430060,China;Changsha Aier Eye Hospital,Changsha 410015,China;Shenyang Aier Eye Hospital,Shenyang 110003,China;Chengdu Aier Eye Hospital,Chengdu 610000,China;Guanzhou Aier Eye Hospital,Guangzhou 510040,China;Hainan Aier New Hope Eye Hospital,Haikou 460000,China;Harbin Aier Eye Hospital,Harbin 150000,China;Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China;Aier School of Ophthalmology,Central South University,Changsha 410000,China)

机构地区：[1]北京爱尔英智眼科医院,北京100021 [2]爱尔角膜病研究所,北京100021 [3]首都医科大学附属北京路河医院眼科,北京101149 [4]重庆眼视光医院,重庆40000 [5]汉口爱尔眼科医院,武汉430060 [6]长沙爱尔眼科医院,长沙410015 [7]沈阳爱尔眼科医院,沈阳110003 [8]成都爱尔眼科医院,成都610000 [9]广州爱尔眼科医院,广州510040 [10]海南爱尔新希望眼科医院,海口460000 [11]哈尔滨爱尔眼科医院,哈尔滨150000 [12]首都医科大学附属北京同仁医院、北京同仁眼科中心北京市眼科研究所,北京100730 [13]中南大学爱尔眼科学院,长沙410000

出　　处：《眼科》2024年第2期120-125,共6页Ophthalmology in China

摘　　要：目的分析眼科门诊干眼患者的临床特征。设计多中心临床研究研究对象爱尔集团北京、重庆、汉口、长沙、沈阳、成都、广州、哈尔滨8个眼科医院十眼门诊4497例初诊为十眼的患者方法回顾性分析2017年6月至2019年6月8个城市爱尔眼科医院初诊为干眼患者的临床资料。所有患者均行眼表疾病指数问卷量表(OSDI)调查、中国干眼问卷量表调查,荧光染色泪膜破裂时间(FBUT)、角膜荧光染色、泪液分泌试验(ST)及脸板腺检查。将十眼患者分为南方(重庆、武汉、长沙、成都、广州)、北方(北京、沈阳、哈尔滨)两组干眼类型分为水液缺乏型、脸板腺功能障碍(MCD)相关型及混合型。干眼严重程度分为轻度、中度及重度主要指标OSDI评分、中国干眼问卷量表得分,FBUT、ST、脸板腺评分。结果4497例患者中水液缺乏型127例(3.0%)。MGD相关型2308例(53.7%),混合型1864(43.4%)。其中MGD4172例,占总数的92.8%。轻度干眼3970例(88.3%)、中度381例(8.5%)、重度119例(2.6%)。北方组患者的ST为(8.1±6.6)mm,明显低于南方组患者的(9.6±7.4)mm(t=-6.470.P<0.001);北方组患者的0SDI评分(22.3±14.4),明显高于南方组患者的(20.7±13.2)(t=3.652,P<0.001);北方组患者的脸板腺分级评分(1.6±0.7),明显高于南方组患者的(1.5±0.7)(t=5.351,P<0.001)。北方的中度及重度干眼患者比例(9.9%,3.5%)较南方(5.4%,0.9%)高(X=52.669,P<0.001)。结论MCD相关的干眼在中国干眼门诊患者中比例较高;中国北方干眼患者中度及重度比例较南方高。Objective To analyze the clinical characteristics associated with dry eye disease(DED)in China.Design Mulicenter clinical research.Participants A total of 4497 patients with a diagnosis of DED from 8 Aier Eye Hospitals(Shenyang,Beijing.Harbin.Chongqing,Changsha,Chengdu,Wuhan and Guangzhou)in China.Methods The clinical data of patients with DED from June 2017 to June 2019 were collected.The Ocular Surface Disease Index(OSDI),the Chinese Dry Eye Questionnaire was administered,and ocular surface staining,Schirmer's test,and fluorescein breakup time test(FBUT)were performed,and meibomian scores were calculated.The patients were classified into North group(Beijing,Shenyang,Harbin)and South group(Chongqing,Wuhan.Changsha,Chengdu,Guangzhou).The types of DED were purely aqueous deficient,purely evaporative and mixed-type groups.The severity of DED was graded into mild,moderate and severe.Main Outcome Measures OSDI,China Dry Eye Questionnaire,FBUT,Schirmer's test,corneal fluorescent staining and meibomian gland score.Results A total of 4497 patients were included in the study.127 cases(3.0%)were classified as having purely aqueous-deficient dry eye,2308 cases(53.7%)were classified as having purely evaporative dry eye resulting from meibomian gland dysfunction(MCD),and 1864 cases(43.4%)were classified as having mixed-type dry eye.Overall,92.8%of these patients showed signs of MGD.Among the patients,3970 cases(88.3%)were mild,381 cases(8.5%)were moderate and 119 cases(2.6%)were severe.The Schirmer test in North group(8.1±6.6 mm)was lower than that in South group(9.6±7.4)mm(t=-6.470,P<0.001).OSDI in North group(22.3±14.4)was higher than that in South group(20.7±13.2)(t=3.652,P<0.001),and meibomian scores in North group(1.6±0.7)was higher than that in South group(1.5±0.7)(t=5.351,P<0.001).The proportions of moderate(9.9%)and severe(3.5%)DED were higher in North group than that in South group(5.4%,0.9%).Conclusion The proportion of dry eye patients associated with MGD is very high in many dry eye clinics in China.The pro

关 键 词：干眼 脸板腺功能障碍 多中心研究 

分 类 号：R777.34[医药卫生—眼科]