lncRNA-MEG3在鼻咽鳞癌患者中的表达变化及临床意义研究  

Study on the Expression Change and Its Clinical Significance of lncRNA-MEG3 of Patients with Nasopharyngeal Squamous Cell Carcinoma

作　　者：强化龙 王伟 杨家玮 QIANG Hualong;WANG Wei;YANG Jiawei(Department of Otorhinolaryngology Head and Neck Surgery,the First Affiliated Hospital of Bengbu Medical University,Bengbu 233000,China;不详)

机构地区：[1]蚌埠医科大学第一附属医院耳鼻咽喉头颈外科,安徽蚌埠233000

出　　处：《中国医学创新》2024年第12期18-21,共4页Medical Innovation of China

基　　金：蚌埠医学院自然科学重点项目(2021byzd137)。

摘　　要：目的:探究分析lncRNA-MEG3在鼻咽鳞癌患者中的表达变化情况。方法:选取2022年6月—2023年6月蚌埠医科大学第一附属医院的96例鼻咽鳞癌患者为研究对象,将鼻咽癌组织作为观察组,癌旁组织作为对照组。检测及比较两组的组织lncRNA-MEG3表达情况,并比较观察组中不同年龄、性别、吸烟史及临床病理参数(分化类型、TNM分期和淋巴结转移)患者的组织lncRNA-MEG3表达情况。结果:观察组的组织lncRNA-MEG3相对表达量及高表达率均显著低于对照组,差异均有统计学意义(P<0.05);观察组中不同年龄、性别及吸烟史患者的组织lncRNA-MEG3相对表达量及高表达率比较,差异均无统计学意义(P>0.05);观察组中分化类型低分化、TNM分期Ⅲ+Ⅳ期和有淋巴结转移患者的组织lncRNA-MEG3相对表达量及高表达率均显著低于分化类型高分化、TNM分期Ⅰ+Ⅱ期和无淋巴结转移患者,差异均有统计学意义(P<0.05)。结论:lncRNA-MEG3在鼻咽鳞癌患者中呈现低表达状态,且不同分化类型、TNM分期和淋巴结转移患者的差异显著,因此在鼻咽鳞癌患者中的检测价值较高。Objective:To investigate and analyze the expression change situation of lncRNA-MEG3 in patients with nasopharyngeal squamous cell carcinoma.Method:A total of 96 patients with nasopharyngeal squamous cell carcinoma in the First Affiliated Hospital of Bengbu Medical University from June 2022 to June 2023 were chosen as the research objects,and the nasopharyngeal carcinoma tissue of patients were as the observation group,the paracancerous tissue of patients were as the control group.Then the tissue lncRNA-MEG3 expression of two groups were detected and compared,and the tissue lncRNA-MEG3 expression of observation group with different ages,gender,smoking history and clinical pathological parameters(differentiation types,TNM stages and lymph node metastasis)were compared.Result:The relative expression level and high expression rate of tissue lncRNA-MEG3 of observation group were significantly lower than those of control group,the differences were statistically significant(P<0.05);the relative expression levels and high expression rates of tissue lncRNA-MEG3 of observation group with different ages,gender and smoking history were compared,the differences were not statistically significant(P>0.05).In the observation group,the relative expression levels and high expression rates of lncRNA-MEG3 in tissues with low differentiation type,Ⅲ+Ⅳ TNM stage and lymph node metastasis were significantly lower than those with high differentiation type,Ⅰ+Ⅱ TNM stage and no lymph node metastasis,the differences were statistically significant(P<0.05).Conclusion:The expression of lncRNA-MEG3 in patients with nasopharyngeal squamous cell carcinoma is lower,and the differences of patients with different differentiation types,TNM stages and lymph node metastasis are significant,so its detection value in patients with nasopharyngeal squamous cell carcinoma is higher.

关 键 词：lncRNA-MEG3 鼻咽鳞癌 病灶组织 癌旁组织 临床病理 

分 类 号：R739.63[医药卫生—肿瘤]