新发难治性癫痫持续状态/热性感染相关性癫痫综合征:癫痫持续状态诊疗的新挑战  

New onset refractory status epilepticus/febrile infection-related epilepsy syndrome:the new challenge in the diagnosis and treatment of status epilepticus

作　　者：王萱 江文 Wang Xuan;Jiang Wen(Department of Neurology,Xijing Hospital,Air Force Military Medical University,Xi′an 710032,China)

机构地区：[1]空军军医大学西京医院神经内科,西安710032

出　　处：《中华神经科杂志》2024年第4期309-314,共6页Chinese Journal of Neurology

基　　金：国家自然科学基金(81771406)。

摘　　要：新发难治性癫痫持续状态(NORSE)及其亚类热性感染相关性癫痫综合征(FIRES)常以难治性癫痫持续状态起病,具有高病死率、高致残性的特点。由于发病机制不清,诊疗极具挑战。文中将从NORSE/FIRES定义、病因与致病机制、临床特点、治疗与预后等多个方面进行评述。New onset refractory status epilepticus(NORSE)and its subcategory,febrile infection-related epilepsy syndrome(FIRES)are rare and devastating conditions,initial symptoms of which are often refractory status epilepticus.NORSE/FIRES is characterized by high mortality and disability,but unfortunately,due to the unclear pathogenesis,the diagnosis and treatment of NORSE/FIRES are very challenging.This editorial aims to summarize the key points and recent developments in the etiology,pathophysiology,diagnosis and management of these challenging conditions.

关 键 词：新发难治性癫痫持续状态 热性感染相关性癫痫综合征 药物难治性癫痫 免疫治疗 

分 类 号：R742.1[医药卫生—神经病学与精神病学]