外周起源的运动障碍疾病研究进展  

Research progress of peripherally-induced movement disorder

作　　者：张绍乙 杨晓东[1] 万新华[2] 吴逸雯[1] Zhang Shaoyi;Yang Xiaodong;Wan Xinhua;Wu Yiwen(Department of Neurology,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Center for Diagnosis and Treatment of Parkinson′s Disease,Shanghai 200025,China;Department of Neurology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]上海交通大学医学院附属瑞金医院神经内科帕金森病诊疗研究中心,上海200025 [2]中国医学科学院北京协和医院神经科,北京100730

出　　处：《中华神经科杂志》2024年第4期401-407,共7页Chinese Journal of Neurology

基　　金：国家自然基金面上项目(81870887,82171239);上海交通大学医学院“研究型医师”项目。

摘　　要：外周起源的运动障碍疾病是指在非中枢神经系统损伤后出现不自主运动症状的一组运动障碍疾病。其临床表现包括不自主运动增多和运动减少,可累及全身多个部位。该病的诊断主要依靠外周损伤与运动障碍发生的时间和空间关系。目前该病的病因、发病机制及治疗策略尚存争论。文中对外周起源的运动障碍疾病的临床表现、分类、诊断、鉴别诊断、治疗策略及潜在发病机制进行综述,旨在增加临床医师对疾病的认识,避免在临床诊疗中出现漏诊和误诊。Peripherally-induced movement disorders(PIMD)are a group of involuntary movements that emerge after an injury to a body part outside the central nervous system.The phenomenology of PIMD encompasses both hyperkinesia and hypokinesia involving multiple parts of the body.The diagnosis of this disease mainly relies on the temporal and spatial relationship between peripheral injuries and movement disorders.The etiology,pathogenesis and treatment of PIMD have been a matter of debate.This article will review the clinical features,classification,diagnosis,treatment and possible pathogenesis of PIMD,and discuss the limitations and controversies of PIMD-related researches,aiming to advance the understanding of PIMD and avoid clinical misdiagnosis.

关 键 词：运动障碍 外周 创伤 损伤 

分 类 号：R741[医药卫生—神经病学与精神病学]