液体活检在肝癌中的研究进展  

Research progress in the liquid biopsy in hepatocellular carcinoma

作　　者：梁人山 张育 陈祖涛[1] 冯婷婷[1] Liang Renshan;Zhang Yu;Chen Zutao;Feng Tingting(Department of Infection,First Affiliated Hospital of Soochow University,Suzhou 215026,Jiangsu,China)

机构地区：[1]苏州大学附属第一医院感染科,江苏苏州215026

出　　处：《肝癌电子杂志》2024年第1期30-33,共4页Electronic Journal of Liver Tumor

基　　金：吴阶平医学基金会临床科研专项资助基金(320.6750.2023-22-5)。

摘　　要：原发性肝癌现位居我国新发癌症第4位与癌症死亡病因第2位,已严重威胁到国民的生命和健康。因其发病隐匿且无特异临床表现,所以肝癌的早期诊断率较低,往往发现时已进展至晚期且预后较差。因此,现代医学迫切需要寻求新型的检测方法以实现对原发性肝癌的早期诊断、实时监测及治疗评估等。液体活检这一新型检测方法便是其中之一,目前不少研究均表明液体活检在肝癌的早期诊断、靶向治疗、转移复发及预后评估等方面具有重大意义。该综述旨在简单介绍目前液体活检在肝癌研究中的相关进展。At present,primary hepatocellular carcinoma ranks fourth common malignant tumor and second tumor cause of death in China,seriously threatening the pubic life and health.Because of its hidden incidence and non-specific clinical manifestations,the early diagnosis rate of primary liver cancer is low.When liver cancer is found,the condition often have progressed to the advanced stage and the prognosis is very poor.Therefore,modern medicine there is an urgent need for new detection methods to early diagnosis,real-time monitoring and effective treatment of liver cancer."Liquid biopsy"is one of the new detection methods.Many studies have shown that liquid biopsy is of great significance in the early diagnosis,targeted treatment,metastasis,recurrence and prognostic evaluation of liver cancer.The purpose of this review is to briefly introduce the research progress of liquid biopsy in hepatocellular carcinoma.

关 键 词：原发性肝癌 液体活检 循环肿瘤细胞 外泌体 血小板 

分 类 号：R735.7[医药卫生—肿瘤]