口腔鳞状细胞癌嗜神经侵袭的研究进展  

Research progress on perineural invasion of oral squamous cell carcinoma

作　　者：李冰芷 刘云坤 王文轩 侯泽宇 唐金茹 李龙江[1] Li Bingzhi;Liu Yunkun;Wang Wenxuan;Hou Zeyu;Tang Jinru;Li Longjiang(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Dept.of Head and Neck Oncology,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、四川大学华西口腔医院头颈肿瘤外科,成都610041

出　　处：《国际口腔医学杂志》2024年第3期362-367,共6页International Journal of Stomatology

基　　金：国家自然科学基金(82141130,82372735)。

摘　　要：口腔鳞状细胞癌(OSCC)是头颈部最常见的恶性肿瘤,具有侵袭、转移、复发的特点,严重影响患者的生命健康。嗜神经侵袭(PNI)是OSCC一个常见且隐匿的病理学特征,降低了患者的生存率,但目前临床上对这种肿瘤高危生物学行为的认识仍不足。近年的研究发现PNI是肿瘤与神经双向的信号交互过程,多种细胞、信号分子参与其中,有可能成为未来治疗干预的靶点。本文就OSCC中PNI的分子病理机制、对预后的影响和临床治疗的研究进展作一综述。Oral squamous cell carcinoma(OSCC)is the most common malignant tumor in the head and neck.OSCC seriously hampers patients’life and health because of its invasion,metastasis,and recurrence characteristics.Perineural invasion(PNI)is a common but occult pathologic characteristic of OSCC that reduces the survival rate of patients.However,the clinical understanding of this high-rick biological behavior ability and mechanism remains insufficient.Recent studies have found that perineural invasion is a reciprocal communication between the tumor and nerves,which involves a variety of cells and molecules,and may become the target of future therapeutic intervention.This article reviews the research progress on the molecular pathological mechanism,prognostic value,and treatment of PNI in OSCC.

关 键 词：口腔鳞状细胞癌 嗜神经侵袭 预后 分子机制 

分 类 号：R781[医药卫生—口腔医学]