前折叠蛋白5的生物学功能与作用机制及其在恶性肿瘤中的研究进展  

Biological function and action mechanism of prefoldin 5 and its advancements in malignant tumors

作　　者：朱孝仁 刘媛媛 姜鉴倬 陈敏斌[1] Zhu Xiaoren;Liu Yuanyuan;Jiang Jianzhuo;Chen Minbin(Department of Oncology,Affiliated Kunshan Hospital of Jiangsu University,Kunshan 215300,China;Clinical Experimental Research Center,Affiliated Kunshan Hospital of Jiangsu University,Kunshan 215300,China)

机构地区：[1]江苏大学附属昆山医院肿瘤科,昆山215300 [2]江苏大学附属昆山医院临床实验研究中心,昆山215300

出　　处：《肿瘤研究与临床》2024年第3期237-240,共4页Cancer Research and Clinic

基　　金：国家自然科学基金(82072712、82273055)。

摘　　要：前折叠蛋白(PFDN)是一种六聚体形式的分子伴侣复合物,是新生蛋白正确折叠所必需的蛋白。PFDN5(又称MM-1)为PFDN的1个亚基,在促进细胞迁移、诱导细胞衰老等方面起着关键作用。多项研究证实,PFDN5的缺失、突变与肿瘤的发生、发展以及患者预后密切相关。文章就近年来针对PFDN5的生物学基础研究及其抗癌前景进行综述,旨在为恶性肿瘤的治疗提供新的潜在靶点。Prefoldin(PFDN),a hexameric chaperone complex,is crucial for the correct folding of nascent proteins.PFDN5,a subunit of PFDN,also known as MM-1,plays an essential role in regulating cell migration and senescence.Emerging evidences suggest that PFDN-5 deletion or mutation significantly contributes to the initiation and progression of multiple cancers and the prognosis of patients.In this paper,recent researches on the biological underpinnings of PFDN-5 and its anti-cancer prospect are reviewed,aiming to provide a novel potential therapeutic target for the treatment of malignancies.

关 键 词：肿瘤 前折叠蛋白 生物学现象 原癌基因蛋白质C-MYC 分子靶向治疗 

分 类 号：R730[医药卫生—肿瘤]