自拟中药汤方联合埃索美拉唑钠治疗难治性非糜烂性胃食管反流病的效果  

Effect of Self-made Traditional Chinese Medicine Decoction Combined with Esomeprazole Sodium in the Treatment of Refractory Non-erosive Gastroesophageal Reflux Disease

作　　者：周新[1] 刘晓敏[1] 张腊梅 袁思琪 田笑笑[1] ZHOU Xin;LIU Xiaomin;ZHANG Lamei;YUAN Siqi;TIAN Xiaoxiao(Department of Gastroenterology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,Henan,China)

机构地区：[1]河南科技大学第一附属医院消化内科,河南洛阳471003

出　　处：《中国药物滥用防治杂志》2024年第3期529-532,556,共5页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探究难治性非糜烂性胃食管反流病应用中药合剂联合埃索美拉唑钠治疗的临床疗效。方法:选取2020年6月—2022年8月本院门诊被确诊为难治性非糜烂性胃食管反流病患者118例作为研究对象。按照随机数字表法分为实验组(60例)与对照组(58例)。实验组采用中药合剂联合埃索美拉唑钠治疗,对照组仅使用埃索美拉唑钠治疗,比较两组临床疗效、病情情况、心理状况、生活质量、24 h食管pH、复发率及不良反应发生率。结果:实验组总有效率、复发率及不良反应发生率与对照组比较,差异无统计学意义(P>0.05);实验组RDQ症状评分、SAS评分、SDS评分低于对照组,SF-36评分高于对照组,24 h食管pH优于对照组,差异有统计学意义(P<0.05)。结论:中药合剂联合埃索美拉唑钠治疗GERD的效果较好,虽然总体疗效与单用埃索美拉唑钠无显著差异性,但中西医联合用药的方法在调节情绪、缓解抑郁焦虑、改善生活质量方面有明显优势,且症状改善时间与单用埃索美拉唑钠相比有所缩短,患者临床满意度更高,值得临床应用。Objective:To explore the clinical efficacy of traditional Chinese medicine mixture combined with esomeprazole sodium in the treatment of refractory non-erosive gastroesophageal reflux disease.Methods:A total of 118 patients with refractory non-erosive gastroesophageal reflux disease diagnosed in our hospital from June 2020 to August 2022 were selected as the study subjects.According to the random number table method,they were divided into experimental group(60 patients)and control group(58 patients).The experimental group was treated with traditional Chinese medicine mixture combined with esomeprazole sodium,while the control group was only treated with esomeprazole sodium.The clinical eficacy,condition,psychological status,quality of life,24 h esophageal pH value,recurrence rate and incidence of adverse reactions were compared between the two groups.Results:There was no significant difference in the total effective rate,recurrence rate and incidence of adverse reactions between the experimental group and the control group(P>0.05).The RDQ symptom score,SAS score and SDS score of the experimental group were lower than those of the control group,the SF-36 score was higher than that of the control group,and the 24 h esophageal pH value was better than that of the control group,the differences were statistically significant(P<0.05).Conclusion:The effect of traditional Chinese medicine mixture combined with esomeprazole sodium in the treatment of GERD is better.Although the overall efficacy is not significantly different from that of esomeprazole sodium alone,the combination of traditional Chinese and Western medicine has obvious advantages in regulating mood,relieving depression and anxiety,and improving quality of life.Meanwhile,the time of symptom improvement is shorter than that of esomeprazole sodium alone,and the clinical satisfaction of patients is higher,whichisworthyofclinical application.

关 键 词：难治性胃食管反流病 非糜烂性胃食管反流病 中药合剂 埃索美拉唑钠 

分 类 号：R571[医药卫生—消化系统]