J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy,older Chinese individuals  

作　　者：Chengzhang Liu Qiguo Meng Yuanxiu Wei Xinyue Su Yuanyuan Zhang Panpan He Chun Zhou Mengyi Liu Ziliang Ye Xianhui Qin 

机构地区：[1]Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,Hefei,Anhui,China [2]institute of Biomedicine,Anhui Medical University,Hefei,Anhui,China [3]Division of Nephrology,Nanfang Hospital,Southern Medical University,National Clinical Research Center for Kidney Disease,State Key Laboratory of Organ Failure Research,Guangdong Provincial Institute of Nephrology,Guangdong Provincial Key Laboratory of Renal Failure Research,Guangzhou Regenerative Medicine and Health Guangdong Laboratory,Guangzhou,Guangdong,China

出　　处：《General Psychiatry》2024年第1期44-52,共9页综合精神医学（英文）

基　　金：National Key Research and Development Program of China(2022YFC2009600,2022YFC2009605);National Natural Science Foundation of China(81973133)。

摘　　要：Background The prospective association of dietary thiamine intake with the risk of cognitive decline among the general older adults remains uncertain.Aims To investigate the association between dietary thiamine intake and cognitive decline in cognitively healthy,older Chinese individuals.Methods The study included a total of 3106 participants capable of completing repeated cognitive function tests.Dietary nutrient intake information was collected through 3-day dietary recalls and using a 3-day food-weighed method to assess cooking oil and condiment consumption.Cognitive decline was defined as the 5-year decline rate in global or composite cognitive scores based on a subset of items from the Telephone Interview for Cognitive Status-modified.Results The median follow-up duration was 5.9 years.There was a J-shaped relationship between dietary thiamine intake and the 5-year decline rate in global and composite cognitive scores,with an inflection point of 0.68 mg/day(95%confidence interval(Cl):0.56 to 0.80)and a minimal risk at 0.60-1.00 mg/day of dietary thiamine intake.Before the inflection point,thiamine intake was not significantly associated with cognitive decline.Beyond the inflection point,each unit increase in thiamine intake(mg/day)was associated with a significant decrease of 4.24(95%Cl:2.22 to 6.27)points in the global score and 0.49(95%Cl:0.23 to 0.76)standard units in the composite score within 5 years.A stronger positive association between thiamine intake and cognitive decline was observed in those with hypertension,obesity and those who were non-smokers(all p<0.05).Conclusions This study revealed a J-shaped association between dietary thiamine intake and cognitive decline in cognitively healthy,older Chinese individuals,with an inflection point at 0.68 mg/day and a minimal risk at 0.60-1.00 mg/day of dietary thiamine intake.

关 键 词：INTAKE shaped cognitive 

分 类 号：R749[医药卫生—神经病学与精神病学]