Chemical Composition, Pharmacological Effects and Clinical Applications of Cinobufacini  

作　　者：ZUO Qian XU Ding-qiao YUE Shi-jun FU Rui-jia TANG Yu-ping 

机构地区：[1]Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility,Shaanxi University of Chinese Medicine,Xi'an(712046),China

出　　处：《Chinese Journal of Integrative Medicine》2024年第4期366-378,共13页中国结合医学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.82274084);Inheritance and Innovation of Traditional Chinese Medicine and Key Scientific Research Project of"Qin Medicine"Development of Shaanxi Administration of Traditional Chinese Medicine(No.2021-02-22-007);Subject Innovation Team of Shaanxi University of Chinese Medicine(No.2019-YL10)。

摘　　要：Chinese medicine cinobufacini is an extract from the dried skin of Bufo bufo gargarizans Cantor,with active ingredients of bufadienolides and indole alkaloids.With further research and clinical applications,it is found that cinobufacini alone or in combination with other therapeutic methods can play an anti-tumor role by controlling proliferation of tumor cells,promoting apoptosis,inhibiting formation of tumor neovascularization,reversing multidrug resistance,and regulating immune response;it also has the functions of relieving cancer pain and regulating immune function.In this paper,the chemical composition,pharmacological effects,clinical applications,and adverse reactions of cinobufacini are summarized.However,the extraction of monomer components of cinobufacini,the relationship between different mechanisms,and the causes of adverse reactions need to be further studied.Also,high-quality clinical studies should be conducted.

关 键 词：CINOBUFACINI chemical composition Chinese medicine pharmacological effect clinical application adverse effect 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]