GLUT1在肝癌炎症性贫血患者中的表达及临床意义  

Expression and clinical significance of GLUT1 in hepatocellular carcinoma patients with inflammatory anemia

作　　者：洪淑芳 杜晓明 杨益敏 李凯强[2] HONG Shufang;DU Xiaoming;YANG Yiming(Jinhua Central Blood Station,Blood Transfusion Research Institute,Jinhua 321000,China)

机构地区：[1]金华市中心血站,金华市输血研究所,浙江金华321000 [2]浙江省人民医院(杭州医学院附属人民医院)输血科

出　　处：《全科医学临床与教育》2024年第4期299-301,共3页Clinical Education of General Practice

基　　金：浙江省医药卫生科技项目(2013ZL010)。

摘　　要：目的探讨促葡萄糖转运蛋白1(GLUT1)在肝癌炎症性贫血患者血清中的表达,分析其临床意义。方法收集84例肝癌住院患者,选取其中C-反应蛋白(CRP)高表达的患者72例,根据血红蛋白(Hb)水平分为贫血组和非贫血组。采用酶联免疫吸附试验(ELISA)检测患者血清中GLUT1、铁调素和白细胞介素-6(IL-6)表达水平。分析GLUT1与肝癌炎症性贫血的关系。结果CRP高表达的肝癌患者中贫血发生率为43.06%(31/72)。贫血组血清中GLUT1、CRP、IL-6和铁调素表达水平均高于非贫血组(U分别=323.00、459.00、312.50、336.00,P均<0.05)。GLUT1与Hb呈负相关,与CRP、IL-6和铁调素均呈正相关,差异均有统计学意义(r分别=-0.50、0.56、0.61、0.60,P均<0.05)。结论GLUT1过度表达可能在肝癌患者炎症性贫血中发挥重要作用。Objective To investigate the expression and the clinical significance of glucose transporter 1(GLUT1)in serum of hepatocellular carcinoma patients with inflammatory anemia.Methods Totally 84 patients with hepatocellular carcinoma were collected,and 72 patients with high expression of C-reactive protein(CRP)were selected and divided into anemia group and non-anemia group according to hemoglobin(Hb)level.The expression levels of GLUT1,hepcidin and interleukin-6(IL-6)in serum were detected by enzyme-linked immunosorbent assay(ELISA).The relationship between GLUT1 and inflammatory anemia of hepatocellular carcinoma was analyzed.Results The anemia incidence rate in patients with high CRP expression was 43.06%(31/72).The expression levels of GLUT1,CRP,IL-6 and hepcidin in serum of anemia group were higher than those of non-anemia group(U=323.00,459.00,312.50,336.00,P<0.05).GLUT1 was negatively correlated with Hb,and positively correlated with CRP,IL-6 and hepcidin,all with statistical significance(r=-0.50,0.56,0.61,0.60,P<0.05).Conclusion Over-expression of GLUT1 may play an important role in patients with liver cancer and inflammatory anemia.

关 键 词：肝癌 炎症性贫血 促葡萄糖转运蛋白1 白细胞介素-6 铁调素 

分 类 号：R735.7[医药卫生—肿瘤] R556[医药卫生—临床医学]