肿瘤引流淋巴结中PD-L1的表达及作用研究进展  

Research progress on the expression and effect of PD-L1 in lymph nodes of tumor drainage

作　　者：闫智恒 齐秀英 张雅芳 YAN Zhiheng;QI Xiuying;ZHANG Yafang(Department of Human Anatomy,School of Basic Medicine,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学基础医学院人体解剖学教研室,哈尔滨150081

出　　处：《国际免疫学杂志》2024年第2期218-222,共5页International Journal of Immunology

摘　　要：肿瘤引流淋巴结(tumor draining lymph node, TDLN)对肿瘤免疫至关重要, 肿瘤细胞产生的一系列细胞因子通过淋巴管在肿瘤转移之前改变了淋巴结的免疫微环境和淋巴结基质, 破坏了TDLN的免疫功能, 为肿瘤细胞的转移创造条件。作为抗肿瘤免疫的重要蛋白, 程序性死亡配体1(programmed death ligand 1, PD-L1)在TDLN中的表达水平和表达位置发生了变化。与此同时, TDLN中PD-L1在肿瘤免疫治疗中起到十分重要的作用。文章介绍了TDLN免疫微环境和淋巴结基质的变化, 阐述了PD-L1在TDLN中的作用、分布以及临床治疗中的机制和作用。Tumor draining lymph node(TDLN)is crucial for tumor immunity.A series of cytokines produced by tumor cells change the immune microenvironment and lymph node matrix through lymph vessels before tumor metastasis,destroying the immune function of TDLN.Creating conditions for tumor cells to metastasize.As an important protein in anti-tumor immunity,the expression level and position of programmed death ligand 1(PD-L1)in TDLN are changed.At the same time,the PD-L1 of TDLN plays a very important role in tumor immunotherapy.This paper introduces the changes of immune microenvironment and lymph node stroma of TDLN,and expounds the role,distribution and mechanism of clinical treatment of PD-L1 in TDLN.

关 键 词：程序性死亡配体1 肿瘤引流淋巴结 免疫微环境 

分 类 号：R730.2[医药卫生—肿瘤]