高海拔地区健康足月新生儿脑氧代谢及脑电活动差异的多中心临床研究方案  

Cerebral oxygen metabolism and brain electrical activity of healthy full-term neonates in high-altitude areas:a multicenter clinical research protocol

作　　者：泽碧 高瑾[2] 赵晓芬[2] 李杨方[2] 张铁松[3] 刘晓梅[3] 毛辉 秦明彩 张奕 杨永礼 和春叶 赵燕 杜琨[2] 刘玲[2] 周文浩 中国高原新生儿医学联盟 ZE Bi;GAO Jin;ZHAO Xiao-Fen;LI Yang-Fang;ZHANG Tie-Song;LIU Xiao-Mei;MAO Hui;QIN Ming-Cai;ZHANG Yi;YANG Yong-Li;HE Chun-Ye;ZHAO Yan;DU Kun;LIU Lin;ZHOU Wen-Hao;Chinese High Altitude Neonatal Medicine Alliance(Department of Neonatology,Kunming Children's Hospital/National Clinical Key Specialty,Kunming 650000,China;Department of Neonatology,Children's Hospital of Fudan University/National Children's Medical Center,Shanghai 201101,China;不详)

机构地区：[1]国家儿童医学中心/复旦大学附属儿科医院新生儿科,上海201101 [2]云南省昆明市儿童医院新生儿科/国家临床重点专科,云南昆明650000 [3]云南省昆明市儿童医院儿科,云南昆明650000 [4]云南大学附属医院产科,云南昆明650000 [5]云南迪庆藏族自治州香格里拉市妇幼保健院儿科,云南迪庆藏族自治州674400 [6]云南迪庆藏族自治州人民医院儿科,云南迪庆藏族自治州674400 [7]云南省丽江市妇幼保健院儿科,云南丽江674100 [8]云南省丽江市人民医院产科,云南丽江674100 [9]云南省怒江傈僳族自治州人民医院儿科,云南怒江671400 [10]广州市妇女儿童医疗中心新生儿科,广东广州510000 [11]不详

出　　处：《中国当代儿科杂志》2024年第4期403-409,共7页Chinese Journal of Contemporary Pediatrics

基　　金：国家自然科学基金资助项目(82060291);云南省周文浩专家工作站(2019IC052)。

摘　　要：高原环境对新生儿神经功能的影响仍需进一步证据积累。通过无创脑近红外光谱技术和振幅整合脑电图检测技术可提供脑氧饱和度及脑电活动数据。该研究通过对不同海拔梯度健康足月新生儿生后3 d内不同时间点进行多次近红外光谱技术、振幅整合脑电图监测,将测得的脑氧饱和度、脑电活动数据在不同海拔间进行比较,并建立相应的参考值范围。该研究包括6家中国高原新生儿医学联盟参与单位,根据所在地海拔分为4个海拔梯度,分别是800 m、1900 m、2400 m和3500 m,每个海拔梯度预计样本量170人。该多中心前瞻性队列研究将为高原环境对新生儿早期脑功能及代谢的影响提供证据支持。Further evidence is needed to explore the impact of high-altitude environments on the neurologic function of neonates.Non-invasive techniques such as cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography can provide data on cerebral oxygenation and brain electrical activity.This study will conduct multiple cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography monitoring sessions at various time points within the first 3 days postpartum for healthy full-term neonates at different altitudes.The obtained data on cerebral oxygenation and brain electrical activity will be compared between different altitudes,and corresponding reference ranges will be established.The study involves 6 participating centers in the Chinese High Altitude Neonatal Medicine Alliance,with altitude gradients divided into 4 categories:800 m,1900 m,2400 m,and 3500 m,with an anticipated sample size of 170 neonates per altitude gradient. This multicenter prospective cohort study aims to provideevidence supporting the impact of high-altitude environments on early brain function and metabolism in neonates.

关 键 词：近红外光谱 脑组织氧饱和度 振幅整合脑电图 高原 新生儿 

分 类 号：R722.1[医药卫生—儿科]