精准胆道外科手术治疗胆囊癌的临床效果  

Clinical effect of precision biliary surgery in the treatment of gallbladder cancer

作　　者：侯龙辉 朱海林[1] 马晓阳[1] HOU Longhui;ZHU Hailin;MA Xiaoyang(Baoji Central Hospital,Baoji 721000,China)

机构地区：[1]宝鸡市中心医院,陕西宝鸡721000

出　　处：《临床医学研究与实践》2024年第13期72-75,共4页Clinical Research and Practice

基　　金：宝鸡市卫生健康委员会科研课题(No.2020-003)。

摘　　要：目的比较精准胆道外科手术与传统手术治疗胆囊癌的临床效果。方法选取2016年1月至2020年6月的120例胆囊癌患者,根据手术治疗方式的不同将其分为对照组和观察组,每组60例。对照组接受传统手术治疗,观察组开展精准胆道外科手术治疗。比较两组的治疗效果。结果观察组的手术时长、首次排气时间、住院时长均短于对照组,术中出血量少于对照组,淋巴结清扫数目多于对照组(P<0.05)。术后第3天,观察组的C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)水平低于对照组(P<0.05)。术后第3天,观察组的糖类抗原199(CA199)、糖类抗原125(CA125)及癌胚抗原(CEA)水平低于对照组(P<0.05)。出院时,观察组的欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ-C30)、卡氏功能状态评分(KPS)评分高于对照组(P<0.05)。观察组的2年生存率高于对照组,并发症总发生率低于对照组(P<0.05)。结论精准胆道外科手术治疗胆囊癌的临床效果显著。Objective To compare the clinical effects of precision biliary surgery and traditional surgery in the treatment of gallbladder cancer.Methods A total of 120 patients with gallbladder cancer from January 2016 to June 2020 were selected and divided into control group and observation group according to different surgical treatment methods,with 60 cases in each group.The control group received traditional surgery treatment,and the observation group received precision biliary surgery.The therapeutic effects of the two groups were compared.Results The operation time,first exhaust time and hospitalization time of the observation group were shorter than those of the control group,the intraoperative blood loss was less than that of the control group,and the number of lymph node dissection was more than that of the control group(P<0.05).On the third day after operation,the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the observation group were lower than those in the control group(P<0.05).On the third day after operation,the levels of carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125)and carcinoembryonic antigen(CEA)in the observation group were lower than those in the control group(P<0.05).At discharge,the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(EORTC QLQ-C30)and Karnofsky Performance Status(KPS)scores of the observation group were higher than those of the control group(P<0.05).The two-year survival rate of the observation group was higher than that of the control group,and the total incidence of complications was lower than that of the control group(P<0.05).Conclusion The precision biliary surgery in the treatment of gallbladder cancer has a significant clinical effect.

关 键 词：精准胆道外科手术 胆囊癌 预后 

分 类 号：R735.8[医药卫生—肿瘤]