RNA甲基化修饰作为肿瘤分子诊断新靶标的价值  

The clinical value of RNA methylation modification as novel tumor molecular diagnostic biomarkers

作　　者：王成 汪俊军 Wang Cheng;Wang Junjun(Department of Clinical Laboratory,Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University&Eastern Theater Command General Hospital,Nanjing 210002,China;Department of Clinical Laboratory,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing 210022,China)

机构地区：[1]南京大学医学院附属金陵医院&东部战区总医院检验科,南京210002 [2]南京中医药大学附属南京中医院(南京市中医院)医学检验科,南京210022

出　　处：《中华检验医学杂志》2024年第4期359-370,共12页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金(82072376,82172360);江苏省自然科学基金(BK20211132)。

摘　　要：恶性肿瘤已成为影响人类健康的主要原因,绝大多数尚缺乏高敏感度和特异度的诊断指标和治疗靶点。RNA甲基化修饰是近年来前沿研究热点,肿瘤组织、细胞和患者外周血中RNA甲基化修饰谱和修饰水平变化与肿瘤发生、发展、预后密切相关,具备作为肿瘤精准诊断和治疗的靶标潜能。尽管目前RNA甲基化修饰检测方法学、作用机制研究和基于RNA甲基化修饰治疗药物的研发仍面临诸多挑战,但其作为肿瘤液体活检指标研究的新方向,展现出良好的临床价值和转化潜能,可为肿瘤的精准诊断、治疗靶标和药物研发提供新的策略和方向。Malignant tumors have become the main threaten of human health,however,highly sensitive and specific diagnostic biomarkers and effective therapeutic targets are still lacking for most cancers currently.RNA methylation modification has been a cutting-edge hotspot in RNA research area in recent years.The dynamic changes of RNA methylation patterns and levels in tumor tissues,cells as well as patients′peripheral blood are closely associated with tumor occurrence,development,and prognosis,and have the potential to serve as precise diagnostic markers and effective therapeutic targets for tumors.Even though several challenges such as RNA methylation detection methods,functional mechanism,and the development of therapeutic drugs based on RNA methylation modification are needed to solve,from lab to clinical practice,RNA methylation still display excellent diagnostic and prognosis performance,which can provide new strategies and evidence for precise diagnosis,treatment targets,and drug development of tumors.

关 键 词：甲基化 RNA修饰 肿瘤 分子诊断技术 

分 类 号：R730.4[医药卫生—肿瘤]