DNA甲基化在鼻咽癌诊疗中的研究进展  

Research progress of DNA methylation in the diagnosis and treatment of nasopharyngeal carcinoma

作　　者：周志伟 钱泰 张琼霞[2] 温鼎声 刘禹利 周宏灏 Zhou Zhiwei;Qian Tai;Zhang Qiongxia;Wen Dingsheng;Liu Yuli;Zhou Honghao(Key Specialty of Clinical Pharmacy,the First Affiliated Hospital of Guangdong Pharmaceutical University,Guangzhou 510080,China;Department of Oncology,the First Affiliated Hospital of Guangdong Pharmaceutical University,Guangzhou 510080,China)

机构地区：[1]广东药科大学附属第一医院临床药学重点专科,广州510080 [2]广东药科大学附属第一医院肿瘤科,广州510080

出　　处：《中华检验医学杂志》2024年第4期455-459,共5页Chinese Journal of Laboratory Medicine

基　　金：广东省医学科研基金(B2021381);广东省中医药管理局资助项目(20212015)。

摘　　要：鼻咽癌是一种常见于中国南方的恶性肿瘤,其发生、发展机制仍未完全明确。但已有大量研究表明DNA甲基化在鼻咽癌的筛查、诊断、治疗及预后评估中具有重要临床应用价值。DNA甲基化通过调控肿瘤发生与发展关联基因的转录、蛋白质表达等方式影响鼻咽癌细胞的分裂周期、生长、侵袭和迁移。此外,鼻咽癌在不同发展阶段的DNA甲基化表达水平存在显著差异,这为鼻咽癌的早诊早治与治疗评估提供了理论指导和临床参考。当前研究表明DNA甲基化检测或可提供一种既简便又高效的鼻咽癌早期筛查手段,同时也可以为无创性筛查方法的发展提供新思路。Nasopharyngeal carcinoma is a common malignant tumor in southern China,and its occurrence and development mechanism are still not fully understood.However,a large number of studies have shown that DNA methylation has important clinical application value in the screening,diagnosis,treatment and prognosis evaluation of nasopharyngeal carcinoma.DNA methylation affects the division cycle,growth,invasion and migration of nasopharyngeal carcinoma cells by regulating the transcription and protein expression levels of genes associated with tumorigenesis and development.In addition,there are significant differences in DNA methylation expression levels in different stages of nasopharyngeal carcinoma,which provides theoretical guidance and clinical reference for the early diagnosis,timely treatment and response evaluation of nasopharyngeal carcinoma.Current studies have shown that DNA methylation detection may provide a simple and efficient early screening method for nasopharyngeal carcinoma,and can also explore new ideas for the development of non-invasive screening methods.

关 键 词：鼻咽肿瘤 DNA甲基化 生物学标记 诊断检查服务 

分 类 号：R739.63[医药卫生—肿瘤]