肺腺癌组织中FNDC1、Napsin A、Smad4表达及临床意义  

The expression and clinical significance of FNDC1,Napsin A,and Smad4 in lung adenocarcinoma tissue

作　　者：江凌 杨彬[2] 毛永忠[3] JIANG Ling;YANG Bin;MAO Yongzhong(Comprehensive Department of Tongji Medical College Affiliated Union Hospital,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院综合科,武汉430022 [2]华中科技大学同济医学院附属协和医院全科医学科,430022 [3]华中科技大学同济医学院附属协和医院外科,430022

出　　处：《临床肿瘤学杂志》2024年第3期255-259,共5页Chinese Clinical Oncology

摘　　要：目的检测肺腺癌中Ⅲ型纤连蛋白结构域1(FNDC1)、天冬氨酸肽酶A(Napsin A)、Smad4的表达及其临床意义。方法回顾性分析2019年12月至2021年12月华中科技大学同济医学院附属协和医院收治的120例肺腺癌患者临床病例资料,收集患者手术切除肿瘤组织和癌旁正常组织。采用免疫组化染色SP法检测肺腺癌组织与癌旁组织中FNDC1、Napsin A、Smad4表达情况,并分析FNDC1、Napsin A、Smad4表达与肺腺癌临床病理特征的关系。随访患者的生存情况,采用Kaplan-meier法绘制生存曲线,生存差异行Log-rank检验;采用Cox风险比例回归模型分析影响肺腺癌患者预后的因素。结果肺腺癌组织中FNDC1阳性表达率为61.67%,高于癌旁组织的20.0%;Napsin A、Smad4阳性表达率分别为41.67%和65.0%,低于癌旁组织的98.33%和90.83%,差异均有统计学意义(P<0.05)。FNDC1、Napsin A、Smad4表达与性别、年龄无关(P>0.05),与TNM分期、病理学分级、肿瘤最大直径、淋巴结转移均有关(P<0.05)。FNDC1阴性表达组患者中位生存时间(OS)为34个月,优于阳性表达组的27个月;Napsin A、Smad4阳性表达组患者中位生存时间分别为30个月和30个月,优于阴性表达组的27个月和25个月;差异均有统计学意义(P<0.05)。单因素Cox风险比例回归模型显示,TNM分期、肿瘤最大直径、淋巴结转移、FNDC1表达、NapsinA表达、Smad4表达是影响肺腺癌OS的因素(P<0.05)。结论肺腺癌组织中FNDC1表达升高,Napsin A、Smad4表达降低,且FNDC1、Napsin A、Smad4表达与临床病理特征、总生存均有关。Objective To detect the expression and clinical significance of type III fibronectin domain 1(FNDC1),aspartate peptidase A(Napsin A),and Smad4 in lung adenocarcinoma.Methods A retrospective analysis was conducted on the clinical data of 120 patients with lung adenocarcinoma admitted to our hospital from December 2019 to December 2021.Surgical resection of cancer tissue and adjacent normal tissue were collected from the patients.Immunohistochemical SP method was used to detect the expression of FNDC1,Napsin A,and Smad4 in lung adenocarcinoma tissues and adjacent tissues,and the relationship between the expression of FNDC1,Napsin A,and Smad4 and the clinical and pathological characteristics of lung adenocarcinoma was analyzed.The patient′s survival status was followed up.Survival curve was drawn by Kaplan-meier method,and survival difference was tested by Log-rank test.Cox proportional regression model was used to analyze the prognostic factors of lung adenocarcinoma patients.Results The positive expression rate of FNDC1 in lung adenocarcinoma tissue was 61.67%,higher than 20.0%in adjacent tissues;The positive expression rates of Napsin A and Smad4 were 41.67%and 65.0%,respectively,which were lower than 98.33%and 90.83%in adjacent tissues,and the differences were statistically significant(P<0.05).The expression of FNDC1,Napsin A,and Smad4 was not related to gender and age(P>0.05),but was correlated with TNM staging,pathological grading,maximum tumor diameter,and lymph node metastasis(P<0.05).The median survival time(OS)of the FNDC1 negative expression group was 34 months,which was better than the 27 months of the positive expression group;The median survival time of the Napsin A and Smad4 positive expression groups was 30 months and 30 months,respectively,which was better than the 27 months and 25 months of the negative expression group;The differences were statistically significant(P<0.05).The univariate Cox risk proportional regression model showed that TNM staging,maximum tumor diameter,lymph node metastasis,F

关 键 词：肺腺癌 Ⅲ型纤连蛋白结构域1 天冬氨酸肽酶A SMAD4 预后 

分 类 号：R734.2[医药卫生—肿瘤]