经鼻入路垂体瘤切除术后并发颅内感染的危险因素分析  

Risk factors of intracranial infection after transnasal resection of pituitary tumour

作　　者：刘兵霞 葛慕莲 葛东明[1] 胡娟[1] 陈杰 徐庶[2] Liu Bingxia;Ge Mulian;Ge Dongming(Department of Neurosurgery,Huai′an First People′s Hospital,Huai′an 223001,China)

机构地区：[1]南京医科大学附属淮安第一医院神经外科,淮安223001 [2]张家港市第一人民医院神经内科

出　　处：《中华保健医学杂志》2024年第2期144-146,共3页Chinese Journal of Health Care and Medicine

基　　金：张家港市卫计系统青年科技项目(ZJGQNKJ201805)。

摘　　要：目的分析经鼻入路垂体瘤切除术后并发颅内感染的危险因素。方法回顾性选取2021年3月~2023年3月淮安市第一人民医院收治的行经鼻入路垂体瘤切除术患者119例。将术后发生颅内感染者纳入感染组(18例),将未发生颅内感染者纳入无感染组(101例)。比较两组患者临床资料及垂体瘤组织相关因子水平,并对经鼻入路垂体瘤切除术后并发颅内感染的危险因素进行单因素及多因素logistic回归分析。结果119例行经鼻入路垂体瘤切除术患者中18例发生术后颅内感染,占15.13%(18119)。经单因素分析显示,年龄≥60岁、手术时间≥4 h、术中出血量≥120 ml、合并脑脊液漏、合并糖尿病、生长激素型肿瘤是经鼻入路垂体瘤切除术患者术后并发颅内感染的影响因素(P<0.05)。经多因素logistic回归分析显示,年龄≥60岁、手术时间≥4 h、合并脑脊液漏、生长激素型肿瘤是经鼻入路垂体瘤切除术后并发颅内感染的独立危险因素(P<0.05)。结论年龄≥60岁、手术时间≥4 h、合并脑脊液漏、生长激素型肿瘤是经鼻入路垂体瘤切除术后并发颅内感染的独立危险因素,临床应积极采取针对性预防措施以降低术后颅内感染发生率,改善患者预后。Objective To retrospectively analyze the risk factors of intracranial infection after transnasal resection of pituitary tumour.Methods From March 2021 to March 2023,119 patients with pituitary tumour who underwent transnasal resection in our hospital were retrospectively analyzed.The patients with intracranial infection after operation were included in the infection group,and those without intracranial infection were included in the non infection group.The clinical data and the levels of tissue related factors of pituitary tumour in the two groups were compared,and the risk factors of intracranial infection after pituitary tumour resection via nasal approach were analyzed by single factor and multifactorial logistic regression analysis.Results Among 119 cases of pituitary tumour resection via nasal approach,18 cases(15.13%,18119)had postoperative intracranial infection.Single factor analysis showed that age≥60 years,operation time≥4 h,intraoperative bleeding≥120 ml,cerebrospinal fluid leakage,diabetes and growth hormone tumor were the influencing factors of intracranial infection in patients undergoing pituitary tumour resection via nasal approach(P<0.05).Multivariate logistic regression analysis showed that age≥60 years,operation time≥4 h,cerebrospinal fluid leakage and growth hormone tumor were independent risk factors for intracranial infection after transnasal pituitary tumour resection(P<0.05).Conclusion Age≥60 years,operation time≥4 hours,cerebrospinal fluid leakage and growth hormone tumor are independent risk factors for intracranial infection after transnasal resection of pituitary tumour.Clinical preventive measures should be taken actively to reduce the incidence of postoperative intracranial infection and improve the prognosis of patients.

关 键 词：经鼻入路垂体瘤切除术 颅内感染 危险因素 

分 类 号：R736.4[医药卫生—肿瘤]