超声医学在脑胶质瘤诊治方面的研究进展  

Advances of ultrasound in the diagnosis and treatment of gliomas

作　　者：张显迪 邱路萍 丁红 ZHANG Xiandi;QIU Luping;DING Hong(Department of Ultrasound,Huashan Hospital,Fudan University,Shanghai 200040,China;National Clinical Research Center for Aging and Medicine,Shanghai 200040,China)

机构地区：[1]复旦大学附属华山医院超声医学科,上海200040 [2]国家老年疾病临床医学研究中心,上海200040

出　　处：《肿瘤影像学》2024年第2期115-120,共6页Oncoradiology

基　　金：国家自然科学基金(82272017)。

摘　　要：脑胶质瘤恶性程度高,患者预后差,胶质瘤的标准化治疗是最大限度地手术切除及放化疗。由于开颅术中“脑漂移”的存在和保护脑功能区的需求,术中超声多种新技术可发挥实时导航定位、协助判断肿瘤边界和识别残留病灶的作用;此外,超声造影和人工智能技术的引入为快速分子病理学诊断展现出广阔的应用前景。同时,超声响应性纳米体系具有临时打开血脑屏障和精确控制药物释放的双重效应,并呈现出优异的生物相容性和针对胶质瘤的高度特异性。本文对上述临床和基础两个方面的研究进展进行述评,旨在为脑胶质瘤的诊疗提供新的参考。Gliomas are highly malignant tumors of the brain with poor prognosis.The standard treatment for gliomas is maximal surgical resection with adjuvant radiotherapy and chemotherapy.Due to the existence of“brain drift”in craniotomy and the need to protect the functional brain area,intraoperative ultrasound plays the role of real-time navigation and localization,assisting in determining the boundary of the tumor and identifying residual foci.The introduction of contrasted-enhanced ultrasound and artificial intelligence technology has demonstrated a promising application prospect for rapid molecular pathology diagnosis.Meanwhile,ultrasound-responsive nanosystems have the dual effects of temporarily opening the blood-brain barrier and precisely controlling drug release,and have demonstrated excellent biocompatibility and high specificity for gliomas.This article reviewed the research progress in both clinical and basic aspects mentioned above,providing new references for the diagnosis and treatment of glioma.

关 键 词：脑胶质瘤 超声 术中超声 纳米医学 

分 类 号：R739.41[医药卫生—肿瘤] R445.1[医药卫生—临床医学]