基于科教融合理念构建药学专业综合实验  

Construction of pharmaceutical comprehensive experiment based on the integration of science and education

作　　者：赵静[1,2] 朱金玲 贺雷雨 李文利[1] 史美云[1] 王贺成[1] ZHAO Jing;ZHU Jinling;HE Leiyu;LI Wenli;SHI Meiyun;WANG Hecheng(School of Life and Pharmaceutical Sciences,Dalian University of Technology,Panjin 124221,China;Aimei Honesty Biopharmaceutical Co.,LTD,Dalian 116000,China)

机构地区：[1]大连理工大学生命科学与药学学院,辽宁盘锦124221 [2]艾美诚信生物制药有限公司,辽宁大连116000

出　　处：《实验室科学》2024年第2期47-52,共6页Laboratory Science

基　　金：大连理工大学教学改革基金重点项目(项目编号:ZD2021018);大连理工大学教学改革基金一般项目(项目编号:YB2021072)。

摘　　要：将科研成果转化为药学本科专业综合实验项目,探究儿茶治疗阿尔茨海默病的分子机制。以网络药理学为主要方法,结合分子对接技术对儿茶中所含化学活性成分、作用靶点、信号通路等进行了研究。从中药系统药理学技术平台数据库中共筛选得到11个儿茶有效成分, 130个儿茶与阿尔茨海默病的共同靶点。Autodock软件进行分子对接结果显示,儿茶中的有效成分可通过调节关键靶点蛋白和相关信号通路治疗阿尔茨海默病。本综合实验的设置有助于提高学生的创新思维和实践能力,鼓励学生用科研的视角解决未知的科学问题。The research results were transformed into a comprehensive experimental project for undergraduates majoring in pharmacy to explore the molecular mechanism of Catechu in the treatment of Alzheimers disease.The active components,targets and signal pathways of Catechu tea were studied by network pharmacology and molecular docking.A total of 11 active ingredients and 130 common targets of Catechu and Alzheimers disease were screened from the database of systems pharmacology.Furthermore,molecular docking with autodock software has shown that the active components in Catechu can be used to treat Alzheimers disease by regulating key targets and related signaling pathways.The setting of this comprehensive experiment helps to improve studentsinnovative thinking and practical ability,and encourage students to solve unknown scientific problems from the perspective of scientific research.

关 键 词：药学专业 科教融合 综合实验 网络药理学 

分 类 号：R961.1[医药卫生—药理学]