Distribution of gene polymorphisms associated with aspirin antiplatelet in the Han NSTEMI population  

作　　者：LI Liu-shui WANG Fei ZHOU Ao YANG Qing LIU Xian-jun 

机构地区：[1]Beijing Luhe Hospital,Capital Medical University,Beijing 101149,China [2]Shanghai Jinshan TCM-Integrated Hospital,Shanghai 201501,China [3]Beijing Chaoyang District Dongba Second Community Health Service Center,Beijing 100015,China

出　　处：《Journal of Hainan Medical University》2024年第2期20-25,共6页海南医学院学报（英文版）

基　　金：Capital Clinical Characteristic Application Research Project(No.Z181100001718144);Beijing Tongzhou District Science and Technology Plan Project(No.KJ2017CX036-06);In-hospital Project of Shanghai Jinshan District Integrated Traditional Chinese and Western Medicine Hospital(No.2022-1)。

摘　　要：Objective:To analyze the genotype and allele distribution characteristics of GPⅢa PLA2(rs5918),PEAR1(rs12041331),and PTGS1(rs10306114)genes related to the antiplatelet pharmacological effects of aspirin,providing reference for individualized treatment of Chinese Han NSTEMI patients.Methods:A total of 107 Han patients with NSTEMI in Beijing Luhe Hospital affiliated to Capital Medical University from January 2016 to December 2022 were selected as the research subjects.The genotypes of GPⅢa PLA2(rs5918),PEAR1(rs12041331)and PTGS1(rs10306114)were detected by fluorescence staining in situ hybridization.The frequency distribution and allele distribution of genotype were analyzed.The results were analyzed whether there were statistical differences in the distribution of related alleles between the Han NSTEMI population and some populations in the 1000 Genomes database.Results:In the Han NSTEMI population,the genotype frequencies of GPⅢa PLA2(rs5918)locus were TT 97.20%,TC 2.80%and CC 0%,the allele frequencies were T 98.60%and C 1.40%.The genotype frequencies of PEAR1(rs12041331)locus were GG 42.06%,GA 44.86%and AA 13.08%,the allele frequencies were G 64.49%and A 35.51%.The genotypes at the PTGS1(rs10306114)locus were all AA(100%),no AG or GG genotype was found.Conclusion:In the NSTEMI population of Han nationality,the mutation at GPⅢa PLA2(rs5918)site related to aspirin antiplatelet pharmacology is rare,and there is no mutation at PTGS1(rs10306114)site.Wild homozygotes are dominant in these two gene loci,while mutations in PEAR1(rs12041331)are more common.Some of the findings in this study are similar to those in previous reports or other populations included in the relevant database;however,some results differ from previous reports or other populations。

关 键 词：ASPIRIN ANTIPLATELET Non-ST-segment elevation myocardial INFARCTION Gene polymorphism Genotype distribution 

分 类 号：R54[医药卫生—心血管疾病]