补阳还五汤联合丁苯酞治疗气虚血瘀型慢性脑缺血的临床观察  

Clinical Observation of Buyang Huanwu Decoction Combined with Butylphthalein in the Treatment of Chronic Cerebral Ischemia Patients with Qi Deficiency and Blood Stasis

作　　者：李润泽 陈思宇 王宏 徐磊 LI Run-ze;CHEN Si-yu;WANG Hong;XU Lei(The First School of Clinical Medicine,Anhui University of Traditional Chinese Medicine,Hefei 230038,China)

机构地区：[1]安徽中医药大学第一临床医学院,安徽合肥230038

出　　处：《云南中医中药杂志》2024年第4期72-77,共6页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

基　　金：安徽中医药大学新安医学教育部重点实验室开放基金项目(2020xayx12)。

摘　　要：目的观察补阳还五汤联合丁苯酞治疗气虚血瘀型慢性脑缺血的临床观察。方法选取2021年8月—2022年8月就诊于安徽中医药大学第一附属医院脑病科,且符合纳入标准的气虚血瘀型慢性脑缺血患者60例,随机分为对照组和治疗组,每组30例。对照组常规予以丁苯酞治疗,治疗组予以补阳还五汤合并丁苯酞治疗2月。针对所有患者治疗前后予以中医证候疗效标准及积分量表、眩晕障碍评定量表(DHI)、蒙特利尔认知评估量表(MoCA)、简易精神状态量表(MMSE)、颅脑磁共振灌注成像(PWI)数据评分进行监测。结果对照组临床总有效率(73.33%)、治疗组临床总有效率(86.67%),治疗组总有效率明显高于对照组有效率(P<0.05),中医症状评分、DHI、MoCA、MMSE、PWI数据对照组评分明显高于治疗组(P<0.05)。结论丁苯酞能有效治疗气虚血瘀型慢性脑缺血,但补阳还五汤联合丁苯酞在治疗气虚血瘀型慢性脑缺血效果更加显著(P<0.05)。Objective:To study the clinical observation of Buyang Huanwu Decoction combined with butylphthalein in the treatment of chronic cerebral ischemia(CCI)with Qi deficiency and blood stasis.Methods:From August 2021 to August 2022,60 CCI patients with qi-deficiency and blood-stasis who met the inclusion criteria were selected and randomly divided into a control group and a treatment group,30 cases each group.The control group was routinely treated with butylphthalein and the treatment group was treated with Buyang Huanwu Decoction combined with butylphthalein for 2 months.For all the patients before and after treatment,TCM syndrome efficacy standard and score scale,Vertigo Disorder Rating Scale(DHI),Montreal Cognitive Assessment Scale(MoCA),Simple Mental State Scale(MMSE),cranial magnetic resonance perfusion-weighted imaging(PWI)data scores were used to monitor.Results:The total clinical effective rate of the control group was 73.33%and that of the treatment group was 86.67%,and the total effective rate of the treatment group was significantly higher than that of the control group(P<0.05),and the scores of TCM symptom score,DHI,MoCA,MMSE and PWI data of the control group were significantly higher than that of the treatment group(P<0.05).Conclusion:Butylphthalein can effectively treat chronic cerebral ischemia patients with qi deficiency and blood stasis,but Buyang Huanwu Decoction combined with butylphthalein has more significant effect in treating chronic cerebral ischemia with qi deficiency and blood stasis type(P<0.05).

关 键 词：补阳还五汤 丁苯酞 气虚血瘀型慢性脑缺血 颅脑磁共振灌注成像 

分 类 号：R743.9[医药卫生—神经病学与精神病学]