Analysis of clinical characteristics of leptomeningeal metastasis with band-like high signal in the brainstem  

作　　者：LIN Hui-xia LIU Ting YANG Yi-hao LI Fei LIANG Bin-ji LI Li-juan LI Zhi-qun LI Qifu 

机构地区：[1]Department of Neurology,the First Affiliated Hospital of Hainan Medical University,Haikou 570102,China [2]Key Laboratory of Tropical Brain Science Research and Translation in Hainan Province Hainan,Haikou 570102,China

出　　处：《Journal of Hainan Medical University》2024年第4期23-28,共6页海南医学院学报（英文版）

基　　金：Hainan Clinical Medical Center Construction Project(2021);Excellent Talent Team of Hainan Province(No.QRCBT202121);Key R&D Program of Hainan Province(No.ZDYF2022SHFZ109)。

摘　　要：Objective:The aim was to analyse the clinical features of leptomeningeal metastasis with banded high signal in the brainstem.Methods:In this paper,we report two cases of lung adenocarcinoma with soft meningeal metastasis,collected from the First Affiliated Hospital of Hainan Medical College,and searched the databases of CNKI,Wanfang,VIP,PubMed,Web of Science,and other databases which reported the MRI manifestation of"brainstem bandlike high signal",and collected the patients'past medical history,symptoms,signs,genetic findings,cerebrospinal fluid manifestation,treatment,and prognosis.Result:A total of 28 patients were included,of whom 26 had a history of lung adenocarcinoma and 2 were found to have occupational changes in the lungs.Magnetic resonance imaging(MRI)showed a band-like high signal in the ventral part of the brainstem on T2-FLAIR,symmetrical on both sides,which could extend to the cerebellar peduncles,with high signals on diffusion-weighted imaging(DWI),low signals on apparent diffusion coefficient(ADC),and long T1 signals on T1-weighted imaging,long T2 signals on T2 weighted imaging,and no long T2 signals on enhancement scan.T1-weighted imaging was a long T1 signal,T2-weighted imaging was a long T2 signal,and no enhancement was seen on enhanced scanning.Conclusion:It is important to recognize leptomeningeal metastasis of lung cancer,and the non-enhancing band of high signal in the brainstem on T2-FLAIR and DWI is likely to be the characteristic manifestation of leptomeningeal metastasis of non-small cell lung cancer.

关 键 词：Leptomeningeal metastasis Band-like high signal Lung adenocarcinoma Magnetic resonance imaging Ce-rebrospinal fluid Blood-brain barrier 

分 类 号：R73-37[医药卫生—肿瘤]