Immunological disturbance effect of exogenous histamine towards key immune cells  

作　　者：Yanan Liu Huan Li Chong Wang Shanjun Chen Renjie Lian Weiqiang Wang Linglin Fu Yanbo Wang 

机构地区：[1]Food Safety Key Laboratory of Zhejiang Province,School of Food Science and Biotechnology,Zhejiang Gongshang University,Hangzhou 310018,China [2]Jinghai Group Co.,Ltd.,Rongcheng 264307,China [3]Jinhua Jinnian Ham Co.,Ltd.,Jinhua 321041,China [4]School of Food and Health,Beijing Technology and Business University,Beijing 100048,China

出　　处：《Food Science and Human Wellness》2024年第4期1856-1863,共8页食品科学与人类健康（英文）

基　　金：financially supported by the Key Project of Zhejiang Provincial Natural Science Foundation of China(LZ22C200003);the National Natural Science Foundation of China(32072290)。

摘　　要：Histamine in food has attracted widespread attention due to the potential toxicity and associated health risk.However,its influences on immunological components,especially the function of key immune cells,are still poorly known.In this work,we explored the effects of exogenous histamine on the function of key immune cells such as intestinal epithelial cells,dendritic cells,and T cells.The results showed that histamine could affect the expression of allergy-related genes in CMT93 cells at a high dose of histamine.Moreover,it’s found that histamine could cause an imbalance in the levels of relevant immune factors secreted by dendritic cells and T cells,especially those related to allergy.At the same time,the proportion of MHC class IIpositive dendritic cells and the proportion of T helper 2(Th2)cells in CD4^(+)T cells increased after histamine stimulation.We concluded that the presence of a certain level of histamine in food may affect the expression of allergy-related cytokines,disrupt the balance of the immune homeostasis,and potentially lead to adverse immune reactions.This work demonstrated the importance of including the estimation of histamine’s immune safety in aquatic products rather than merely considering the potential risk of food poisoning.

关 键 词：HISTAMINE Immunological disturbance Food allergy Immune factor Edible safety 

分 类 号：TS201.6[轻工技术与工程—食品科学]