Effects of low molecular weight polysaccharide from Sargassum thunbergii against palmitic acid-induced intracellular lipid accumulation in 3T3-L1 adipocyte and HepG2 cells  

作　　者：Hyo-Geun Lee D.P.Nagahawatta M.J.M.S.Kurera Kyung-Mo Song Yun-Sang Choi You-Jin Jeon Min-Cheol Kang 

机构地区：[1]Department of Marine Life Sciences,Jeju National University,Jeju 63243,Republic of Korea [2]Department of Biotechnology,Faculty of Agriculture and Plantation Management,Wayamba University of Sri Lanka,Makandura,Gonawila(NWP)60170,Sri Lanka [3]Research Group of Food Processing,Korea Food Research Institute,245,Wanju 55365,Republic of Korea

出　　处：《Food Science and Human Wellness》2024年第4期2244-2252,共9页食品科学与人类健康（英文）

基　　金：supported by Korea Institute of Marine Science&Technology Promotion(KIMST)funded by the Ministry of Oceans and Fisheries,Korea(20220488)。

摘　　要：Low molecular weight polysaccharides can be isolated from Sargassum thunbergii(LMPST)and in vitro experiments were conducted to evaluate the inhibitory effects on lipids.Two natures of LMPST were attained from S.thunbergii and appraised their LMPST on palmitic acid(PA)induced lipid accretion in Hep G2,and 3T3-L1 cells.LMPST treatment lessened lipid deposition and intracellular free fatty acid and triglyceride intensities in PA-treated above mentioned cells.The mechanistic study publicized that LMPST2 significantly suppressed adipogenesis and stimulated the PA-treated 3T3-L1 cells occupied in the lipolysis pathway.Furthermore,in PA-treated Hep G2 cells,the free fatty acid oxidation was significantly increased by LMPST2.Given these constructive properties of LMPST2 from S.thunbergii,is a potential candidate for diminishing the intracellular lipids,and for a therapeutic agent in those conditions.

关 键 词：Sargassum thunbergii Low molecular weight polysaccharide Lipid accumulation OBESITY Liver steatosis 

分 类 号：TQ460.1[化学工程—制药化工]