Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in mice  

作　　者：Jialu Shi Yan Xu Cheng Liu Shizhi Wang Jin Wang Vijaya Raghavan 

机构地区：[1]Key Laboratory of Environmental Medicine and Engineering,Ministry of Education,and Department of Nutrition and Food Hygiene,School of Public Health,Southeast University,Nanjing 210009,China [2]Department of Bioresource Engineering,Faculty of Agricultural and Environmental Sciences,McGill University,Sainte-Anne-de-Bellevue,QC H9X3V9,Canada

出　　处：《Food Science and Human Wellness》2024年第4期2346-2352,共7页食品科学与人类健康（英文）

基　　金：the financial supporting by the National Key Research and Development Program of China(2022YFF1102400);National Natural Science Foundation of China(32102093);the Natural Science Foundation of Jiangsu Province(BK20210226)。

摘　　要：Food allergy is a significant public health concern globally.Certain probiotics have been found to enhance food allergy by regulating immune-microbe interactions in animal models and patients.However,the effects of Bifidobacterium lactis Probio-M8 on food allergy have not been thoroughly investigated.The present study examined the anti-allergic properties of Probio-M8,particularly in relation to immune response and gut microbiota composition.Results demonstrate that oral administration of Probio-M8 effectively mitigated the allergy symptoms triggered by ovalbumin(OVA)by ameliorating the morphological damage in the jejunum,reducing OVA-specific IgE and histamine levels in the serum,and suppressing Th2 cytokines(interleukin(IL)4 and IL-13)while increasing Th1 cytokines(interferon(IFN)γ)and regulatory T(Treg)cytokines(IL-10 and transforming growth factor(TGF)β1)in the culture supernatants of splenic cells.Furthermore,Probio-M8 effectively altered the diversity and composition of gut microbiota,particularly the relative abundances of Akkermansia_muciniphila in OVA-induced mice.Compared to the OVA group,the Probio-M8 group showed a decrease in the relative abundance of Akkermansia_muciniphila.In conclusion,Probio-M8 demonstrates the potential to alleviate food allergy by regulating the Th1/Th2 response and modulating gut microbiota,thereby offering a novel therapeutic strategy for patients with food allergy.

关 键 词：Food allergy Bifidobacterium lactis Probio-M8 T cell immune response Gut microbiota 

分 类 号：TS201.6[轻工技术与工程—食品科学]