CFL-1在头颈部鳞癌中的表达与患者预后的关系  

The expression and prognosis prediction of CFL-1 in head and neck squamous cell carcinoma

作　　者：赵开 张宇宁 纪帅旗 刘颖 姜涵 ZHAO Kai;ZHANG Yu-ning;JI Shuai-qi;LIU Ying;JIANG Han(Department of Stomatology,The Fourth Affiliated Hospital of Soochow University,Suzhou Dushu Lake Hospital,Medical Center of Soochow University.Suzhou 215000,Jiangsu Province;Department of Preventive Dentistry,Stomatology Hospital,Fujian Medical University,Fujian Provincial Key Laboratory of Stomatology,School of Stomatology of Fujian Medical University.Fuzhou 350000,Fujian Province,China)

机构地区：[1]苏州大学附属第四医院口腔科,苏州市独墅湖医院,苏州大学医学中心,江苏苏州215000 [2]福建医科大学口腔医院预防牙科,福建省口腔疾病重点实验室,福建医科大学口腔医学院,福建福州350000

出　　处：《上海口腔医学》2024年第2期148-155,共8页Shanghai Journal of Stomatology

基　　金：苏州市科技计划项目(自贸区生物医药创新发展强链补链科技专项-医工结合协同创新研究SZM2023015)。

摘　　要：目的:探索Cofilin 1蛋白(Cofilin 1 protein,CFL-1)在头颈部鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)中的表达、预后价值和免疫相关性。方法:在癌症基因组图谱数据库(cancer genome map database,TCGA)和基因表达总数据库(gene expression total databases,GEO)中,分析CFL-1在HNSCC中的表达及预后价值,通过基因集富集分析(gene set enrichment analysis,GESA)、cibersoft明确CFL-1在HNSCC组织中的分子通路。采用SPSS 26.0软件包对数据进行统计学分析。结果:CFL-1在HNSCC组织中显著上调。CFL-1高表达组与较低的总生存率显著相关。多因素Cox生存分析表明,CFL-1表达是HNSCC预后不良的独立预测因素。GESA、cibersoft分析表明,CFL-1表达失调影响多条信号通路,并影响免疫细胞的局部浸润。结论:CFL-1在HNSCC中高表达,并与不良预后显著相关,是HNSCC的潜在标志物。PURPOSE:The purpose of this study was to explore the expression,prognostic value and immune correlation of Cofilin 1 protein(CFL-1)in head and neck squamous cell carcinoma(HNSCC).METHODS:The expression and prognostic value of CFL-1 in head and neck squamous cell carcinoma(HNSCC)was explored in the cancer genome map database(TCGA)and gene expression total databases(GEO),and the potential immune pathway of CFL-1 in HNSCC was revealed by GESA and cibersoft analysis.The data were statistically analyzed using SPSS 26.0 software package.RESULTS:CFL-1 was significantly up-regulated in HNSCC tissue.The expression level of CFL-1 was significantly correlated with the overall survival status of HNSCC.High expression of CFL-1 was significantly associated with a lower overall survival rate.In addition,multivariate Cox survival analysis showed that CFL-1 expression was independent predictors of poor prognosis of HNSCC.GESA and cibersoft analysis showed that the imbalance of CFL-1 expression affected multiple signal pathways and infiltration of immune cells.CONCLUSIONS:CFL-1 is highly expressed in HNSCC and is significantly associated with poor prognosis of NHSCC.It is a potential prognostic marker of HNSCC.

关 键 词：CFL-1 头颈部鳞癌 免疫浸润 预后 标志物 

分 类 号：R739.8[医药卫生—肿瘤]