^(68)Ga-FAPI PET与^(18)F-FDG PET诊断胃肠道恶性肿瘤及转移:Meta分析  

^(68)Ga-FAPI PET and ^(18)F-FDG PET imaging for diagnosinggastrointestinal malignant tumors and metastases:Meta-analysis

作　　者：李祥勇 吴勇[1] 周陈希 陈柯楠 邢春根[1] LI Xiangyong;WU Yong;ZHOU Chenxi;CHEN Kenan;XING Chungen(Department of Gastrointestinal Surgery,the Second Affiliated Hospital of Soochow University,Suzhou 215000,China)

机构地区：[1]苏州大学附属第二医院胃肠外科,江苏苏州215000

出　　处：《中国医学影像技术》2024年第4期559-565,共7页Chinese Journal of Medical Imaging Technology

基　　金：省部共建放射医学与辐射防护国家重点实验室开放课题(GZK1202243);苏州市科技发展计划(SKY2022156)。

摘　　要：目的 采用meta分析评估^(68)Ga-成纤维细胞活化蛋白抑制剂(FAPI)PET与^(18)F-FDG PET显像诊断胃肠道恶性肿瘤及其转移灶的价值。方法 检索并筛选PubMed、Embase、Web of Science和Cochrane Library自建库至2023年4月11日收录的关于对比^(68)Ga-FAPI PET与^(18)F-FDG PET显像诊断胃肠道恶性肿瘤及转移价值的文献并提取相关数据,以Stata 16.0及Review Manager 5.3.5软件进行数据分析。结果 共纳入9篇文献、370例胃肠道恶性肿瘤患者,其中62例伴淋巴转移、29例伴肝转移、17例伴骨转移、50例伴腹膜转移。^(68)Ga-FAPI PET显像在患者及病灶层面诊断胃肠道恶性肿瘤原发灶、淋巴结转移及腹膜转移的敏感度均高于^(18)F-FDG PET(P均<0.05),而二者在患者层面诊断骨转移及肝转移敏感度差异均无统计学意义(P均>0.05)。结论 ^(68)Ga-FAPI PET显像诊断胃肠道恶性肿瘤及转移的价值优于^(18)F-FDG PET。Objective To observe the value of ^(68)Ga-fibroblast activation protein inhibitor(FAPI)PET and ^(18)F-FDG PET imaging for diagnosing gastrointestinal malignant tumors and metastases using meta-analysis.Methods Literature about comparison on the value of ^(68)Ga-FAPI PET and ^(18)F-FDG PET imaging for diagnosing gastrointestinal malignancies and metastases were searched in PubMed,Embase,Web of Science and Cochrane Library from the establishment of database to April 11,2023 and then screened,and the relevant data were extracted and analyzed using Stata 16.0 and Review Manager 5.3.5.Results Totally 9 articles mentioned 370 patients with gastrointestinal malignant tumors were enrolled,including 62 cases with lymphatic metastasis,29 with liver metastasis,17 with bone metastasis and 50 with peritoneal metastasis.The sensitivity of ^(68)Ga-FAPI PET imaging for diagnosing primary lesion,lymph node metastasis and peritoneal metastasis of gastrointestinal malignant tumors were all higher than that of ^(18)F-FDG PET imaging on both patient and lesion level(all P<0.05),but no significant difference of these 2 methods for diagnosing bone metastasis nor liver metastasis was found on patient level(both P>0.05).Conclusion The value of ^(68)Ga-FAPI PET imaging for diagnosing gastrointestinal malignant tumors and metastases was superior to ^(18)F-FDG PET imaging.

关 键 词：胃肠道肿瘤 正电子发射断层显像 荟萃分析 

分 类 号：R735[医药卫生—肿瘤] R817.4[医药卫生—临床医学]