多巴胺系统显像在帕金森病诊断中研究进展  

Research progress of dopaminergic imaging in the diagnosis of Parkinson's disease

作　　者：于淼 白岩 王梅云 陈传亮 YU Miao;BAI Yan;WANG Meiyun;CHEN Chuanliang(Department of Medical Imaging,Zhengzhou University People's Hospital,Henan Provincial People's Hospital,Zhengzhou,Henan 450003,China)

机构地区：[1]郑州大学人民医院河南省人民医院医学影像科,河南郑州450003

出　　处：《中华实用诊断与治疗杂志》2024年第4期420-423,共4页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家重点研发计划项目(2022YFC2406906)。

摘　　要：帕金森病是常见的神经系统退行性疾病,有起病隐匿且病情发展不可逆等特点。目前临床确诊帕金森病缺乏一定的客观依据,而多巴胺系统显像剂可通过与正电子发射断层成像(PET)及单光子发射计算机断层成像(SPECT)技术结合直观评估脑内多巴胺系统完整性及受体数量、功能和分布情况,在帕金森病早期诊断及鉴别诊断中发挥重要作用。本文就多巴胺系统显像在帕金森病诊断中研究进展作一综述。Parkinson's disease(PD)is a common neurodegenerative disease with insidious onset and irreversible progression.Currently,there is a lack of objective basis for clinical diagnosis of PD,while dopaminergic imaging can visually assess the integrity of the dopamine system,and the number,function and distribution of the receptor in the brain through positron emission tomography and single-photon emission computed tomography,so as to play an important role in the diagnosis and differential diagnosis of PD.This paper reviews the research progress of dopaminergic imaging in the diagnosis of PD.

关 键 词：帕金森病 多巴胺系统显像 正电子发射断层成像 单光子发射计算机断层成像 

分 类 号：R742.5[医药卫生—神经病学与精神病学]