术后同步辅助放化疗在乳腺癌患者中的应用效果  

Application effect of postoperative synchronous adjuvant chemoradiotherapy in patients with breast cancer

作　　者：吕晓伟 刘方丽 LYU Xiaowei;LIU Fangli(Comprehensive Treatment and Radiotherapy Ward,Heze Peony People's Hospital,Shandong Province,Heze 274000,China)

机构地区：[1]山东省菏泽市牡丹人民医院综合治疗放疗病区,山东菏泽274000

出　　处：《中国当代医药》2024年第12期87-90,共4页China Modern Medicine

摘　　要：目的探讨对乳腺癌患者采用术后同步辅助放化疗方法完成治疗后获得的临床效果。方法选取2020年2月至2022年8月菏泽市牡丹人民医院收治的60例乳腺癌患者作为研究对象,按照随机数字表法分为参照组(30例)与研究组(30例)。参照组采用术后辅助序贯治疗方法,研究组采用术后同步辅助放化疗治疗方法。比较两组的乳腺癌患者的远处转移率、局部复发率、无疾病进展率、放化疗全程治疗时间、不良反应(胃肠道反应、白细胞减少)总发生率、治疗总有效率。结果研究组乳腺癌患者远处转移率、局部复发率、无疾病进展率同参照组比较,差异无统计学意义(P>0.05);研究组乳腺癌患者放化疗全程治疗时间短于参照组,差异有统计学意义(P<0.05);研究组乳腺癌患者不良反应(胃肠道反应、白细胞减少)总发生率同参照组展开比较,差异无统计学意义(P>0.05);研究组治疗总有效率高于参照组,差异有统计学意义(P<0.05)。结论临床上对乳腺癌患者术后采用同步辅助放化疗方法治疗,同常规序贯疗法比较,可将乳腺癌患者的放化疗全程治疗时间有效缩短,并且在远处转移率、局部复发率、无疾病进展率以及不良反应总发生率方面,差异无统计学意义,进一步说明对乳腺癌患者术后采用同步辅助放化疗方法治疗的价值所在。Objective To explore the clinical effect of postoperative synchronous adjuvant chemordiotherapy for breast cancer patients.Methods A total of sixty patients with breast cancer admitted to Heze Peony People's Hospital from February 2020 to August 2022 were selected as the study objects.According to the random number table method,they were divided into the reference group(30 cases)and the study group(30 cases).The reference group was treated with postoperative adjuvant sequential therapy,while the study group was treated with postoperative adjuvant chemoradiotherapy.The rate of distant metastasis,local recurrence rate,disease-free progression rate,duration of radiotherapy and chemotherapy,initiation time of radiotherapy,and total incidence of adverse reactions(gastrointestinal reactions,leukopenia)were compared between the two groups.Results There were no significant differences in the rate of distant metastasis,local recurrence and no disease progression in the study group compared with the reference group(P>0.05).The whole treatment time of radiotherapy and chemotherapy in the study group was shorter than that in the reference group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions(gastrointestinal reactions,leukopenia)in the study group was compared with that in the reference group,and the difference was not statistically significant(P>0.05).The total effective rate in the study group was higher than that in the reference group,and the difference was statistically significant(P<0.05).Conclusion Clinical use of synchronous adjuvant chemoradiotherapy for postoperative treatment of breast cancer patients can effectively shorten the whole treatment time of chemoradiotherapy and the start time of radiotherapy compared with conventional sequential therapy,and there are no significant differences in the rate of distant metastasis,local recurrence rate,disease-free progression rate and total incidence of adverse reactions.The value of simultaneous adjuvant chemoradiotherap

关 键 词：乳腺癌 术后同步辅助放化疗 序贯治疗 远处转移率 局部复发率 无疾病进展率 不良反应 

分 类 号：R737.9[医药卫生—肿瘤]