不同感兴趣区对鼻咽癌图像引导放疗摆位误差的影响  

The Influence of Different Regions of Interest on Setup Errors in Image-guided Radiation Therapy for Nasopharyngeal Carcinoma

作　　者：陈璐 CHEN Lu(Radiotherapy Center,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032)

机构地区：[1]复旦大学附属肿瘤医院放疗中心,复旦大学上海医学院肿瘤学系,上海200032

出　　处：《中国医疗器械信息》2024年第8期5-7,共3页China Medical Device Information

摘　　要：目的:比较分析鼻咽癌图像引导放疗(IGRT)过程中手动图像配准与不同感兴趣区(ROI)自动图像配准所得结果,为临床实际配准工作提供参考。方法:回顾性分析复旦大学附属肿瘤医院放疗中心2021年6月~2023年6月20例鼻咽癌放疗患者的兆伏级电子射野影像系统(EPID)验证片,以手动配准与大中小不同ROI范围的自动配准进行分组,分析比较各观察组与对照组的摆位误差值及组间相关性。结果:观察组(L)与对照组三个平移方向误差值比较,均呈显著差异(P<0.05);观察组(S)与对照组的VRT及LAT方向误差值呈显著差异(P<0.05),LNG方向误差值无明显差异(P=0.6);观察组(M)与对照组三个平移方向误差值比较均无明显差异。四组配准结果中三个平移方向≤2mm的误差绝对值分布概率分别为:VRT(80%~98%),LNG(62%~95%),LAT(85%~97%)。皮尔逊相关性分析所示各组之间三个方向误差值与另外三组同方向误差值均呈显著正相关,具有统计学意义(P<0.01)。结论:不同感兴趣区范围均对配准结果存在一定影响,其中观察组(M)与对照组无明显差异,可在自动配准系统应用时优先选择适中范围ROI,再根据不同实际情况进行手动调整。Objective:To compare and analyze the results of manual image registration and automatic image registration under different regions of interest(ROI)in image-guided radiotherapy(IGRT)for nasopharyngeal carcinoma,so as to provide reference for clinical registration.Methods:A retrospective analysis was made of the megavolt electronic portal imaging system(EPID)verification films of 20 patients with nasopharyngeal carcinoma undergoing radiotherapy from June 2021 to June 2023 in the Radiation Therapy Center of Fudan University Shanghai cancer center.The automatic registration of small and medium ROI ranges is grouped,and the set-up error value and inter-group correlation between each group and the control group are analyzed and compared.Results:There were significant differences between the observation group(L)and the control group in the three translation direction errors(P<0.05);The observation group(S)and the control group had significant differences in the VRT and LAT direction errors(P<0.05),there was no significant difference in the LNG direction error value(P=0.6);There was no significant difference in the three translation direction error values between the observation group(M)and the control group.The distribution probabilities of the absolute value of the errors in the three translation directions less than or equal to 2mm in the four registration results are:VRT(80%-98%),LNG(62%-95%),and LAT(85%-97%).Pearson correlation analysis showed that the error values in the three directions between each group were significantly positively correlated with the error values in the same direction in the other three groups,which was statistically significant(P<0.01).Conclusion:Different ROI ranges have a certain impact on the registration results,and there is no significant difference between the observation group(M)and the control group.When applying the automatic registration system,a moderate range of ROI can be selected first,and then manually adjusted according to different actual situations.

关 键 词：鼻咽癌 图像引导放疗 电子射野影像系统 感兴趣区 摆位误差 

分 类 号：R730.55[医药卫生—肿瘤]