氯胺酮快速抗抑郁作用机制研究进展  

Research progress on the mechanism of action of the rapid antidepressant effect of ketamine

作　　者：苏荣 李晓凤 杨敏雪 郭艳浩 张亚通[1] SU Rong;LI Xiaofeng;YANG Minxue;GUO Yanhao;ZHANG Yatong(School of Sciences,Hebei University of Science and Technology,Hebei,Shijiazhuang 050018,China;School of Pharmacy,Qingdao University,Shandong,Qingdao 266071,China;Wuya College of Innovation,Shenyang Pharmaceutical University,Liaoning,Shenyang 110016,China)

机构地区：[1]河北科技大学理学院,河北石家庄050018 [2]青岛大学药学院,山东青岛266071 [3]沈阳药科大学无涯创新学院,辽宁沈阳110016

出　　处：《中国医药科学》2024年第7期59-63,共5页China Medicine And Pharmacy

摘　　要：氯胺酮的发现,掀起了作用于N-甲基-D-天门冬氨酸(NMDA)受体(NMDAR)抗抑郁药的研究热潮。氯胺酮发挥抗抑郁的作用机制尚不明确,根据现有研究科学家提出了一系列的假说,如去抑制假说、突触可塑性假说等。谷氨酸(Glu)作为中枢神经系统中重要的兴奋性递质与抑郁症有着密切联系,其中NMDAR在抑郁症治疗中起着关键作用,然而氯胺酮因具有致幻性和成瘾性而存在风险,限制了其应用。尽管如此,了解氯胺酮快速持续抗抑郁作用的治疗靶点和相关信号通路对于研发相关药物有重要作用。The discovery of ketamine has sparked a wave of research on antidepressants that act on the N-methyl-D-aspartate(NMDA)receptor(NMDAR).The mechanism of action by which ketamine exerts antidepressant effects is not yet clear.Based on existing researches,scientists have proposed a series of hypotheses,such as the disinhibition hypothesis,synaptic plasticity hypothesis,etc.Glutamic acid(Glu),as an important excitatory transmitter in the central nervous system,is closely related to depression.Among them,the NMDAR plays a key role in the treatment of depression.However,the hallucinogenic and addictive nature of ketamine poses risks,limiting its application.Nevertheless,understanding the therapeutic targets and related signaling pathways of ketamine’s rapid and sustained antidepressant effects is crucial for the development of related drugs.

关 键 词：抑郁症 氯胺酮 N-甲基-D-天门冬氨酸受体 谷氨酸 抗抑郁 作用机制 

分 类 号：R749.4[医药卫生—神经病学与精神病学]