GDF11生物学功能的研究进展  

Research progress in the biological function of GDF11

作　　者：敬媛媛 胥勋梅[1] 张栋珉 田博文 JING Yuanyuan;XU Xunmei;ZHANG Dongmin;TIAN Bowen(The Third Hospital of Mianyang,Sichuan Provincial Center for Mental Health,Sichuan,Mianyang 621000,China)

机构地区：[1]四川省绵阳市第三人民医院、四川省精神卫生中心,四川绵阳621000

出　　处：《中国医药科学》2024年第8期49-52,共4页China Medicine And Pharmacy

基　　金：四川省绵阳市卫生健康委员会科研课题(201929);四川省绵阳市第三人民医院科研立项课题(202209)。

摘　　要：生长分化因子11(GDF11)是转化生长因子-β超家族的成员之一,近年因其在调节各种组织器官的发育和分化中的多种功能而备受关注。GDF11具有广泛的生物学效应,包括在临床应用中逆转衰老、逆转与年龄相关的病理变化和调节损伤后器官再生的能力等,如逆转年龄相关的心肌肥厚、改善衰老骨骼肌代谢、促进神经血管再生、减少肝脏脂肪变性。但是也有研究报道GDF11对心脏、骨骼肌、肝脏等并不存在有益作用。目前的研究显示GDF11在各个器官系统中的生物学功能存在争议。本文回顾近年来GDF11在各个系统及疾病中的作用,旨在对当前相关研究进行总结归纳,为以GDF11为靶点相关疾病的防治及预后提供理论依据。Growth differentiation factor 11(GDF11)is a member of the transforming growth factor-β superfamily that has received much attention in recent years due to its multiple functions in regulating the development and differentiation of various tissues and organs.Its extensive biological effects include reversing aging in clinical applications,as well as reversing age-related pathological changes and regulating organ regeneration after injury,such as reversing age-related myocardial hypertrophy,improving aging skeletal muscle metabolism,promoting neurovascular regeneration,and reducing liver steatosis.However,some studies have reported that GDF11 does not have beneficial effects on the heart,skeletal muscles,liver,etc.So current research shows that the biological function of GDF11 in various organ systems is controversial.This article reviews the role of GDF11 in various systems and diseases in recent years,aiming to summarize current relevant research and provide a theoretical basis for the prevention,treatment,and prognosis of diseases related to GDF11 as the target.

关 键 词：GDF11 生物学功能 心脏 骨骼肌 大脑 肝脏 

分 类 号：R363[医药卫生—病理学]