子宫内膜癌患者组织内PGK1、VEGF-C表达与病理特征和预后的关系  

Relationship of PGK1 and VEGF-C expression in tissues of patients with endometrial cancer with pathological features and prognosis

作　　者：王昆 陈强 WANG Kun;CHEN Qiang(Department of Pathology,Yulin First Hospital,Yulin,Shaanxi 719000,China;Department of Hand and Foot Microsurgery,Yulin First Hospital,Yulin,Shaanxi 719000,China)

机构地区：[1]陕西省榆林市第一医院病理科,陕西榆林719000 [2]陕西省榆林市第一医院手足显微外科,陕西榆林719000

出　　处：《检验医学与临床》2024年第9期1303-1306,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨子宫内膜癌患者组织内磷酸甘油酸酯激酶1(PGK1)、血管内皮生长因子-C(VEGF-C)表达与病理特征和预后的关系。方法回顾性选取2017年5月至2020年5月榆林市第一医院收治的106例子宫内膜癌患者作为研究对象。采用免疫组化染色法检测子宫内膜癌患者癌组织与癌旁组织内PGK1、VEGF-C表达,比较子宫内膜癌患者癌组织与癌旁组织PGK1、VEGF-C表达。比较不同病理特征子宫内膜癌患者癌组织内PGK1、VEGF-C表达;采用Kaplan-Meier生存曲线分析不同PGK1、VEGF-C表达患者的预后情况。结果子宫内膜癌患者癌组织中PGK1高表达、VEGF-C阳性患者比例显著高于癌旁组织(P<0.05)。PGK1高表达患者低分化、FIGO分期Ⅲ~Ⅳ期和有淋巴结转移患者比例显著高于PGK1低表达患者(P<0.05),VEGF-C阳性患者FIGO分期Ⅲ~Ⅳ期和有淋巴结转移患者比例显著高于VEGF-C阴性患者(P<0.05)。106例子宫内膜癌患者3年生存率为79.25%(84/106);Kaplan-Meier生存曲线结果显示,子宫内膜癌组织PGK1高表达患者3年生存率[67.44%(29/43)]显著低于PGK1低表达患者[87.30%(55/63)],差异有统计学意义(Log-Rankχ^(2)=7.513,P<0.01);VEGF-C阳性患者3年生存率[75.00%(60/80)]显著低于VEGF-C阴性患者[92.31%(24/26)],差异有统计学意义(Lo-Rankχ^(2)=6.527,P<0.01)。结论PGK1、VEGF-C水平与子宫内膜癌的发生和发展密切相关,PGK1高表达、VEGF-C阳性患者疾病进展更严重,预后更差。Objective To investigate the relationship of phosphoglycerate kinase 1(PGK1)and vascular endothelial growth factor-C(VEGF-C)expression in tissues of patients with endometrial cancer with pathological features and prognosis.Methods A total of 106 patients with endometrial cancer treated in Yulin First Hospital from May 2017 to May 2020 were retrospectively selected as the study subjects.Immunohistochemical staining method was used to detect the expression of PGK1 and VEGF-C in cancer tissues and paracancerous tissues of patients with endometrial cancer.The expression of PGK1 and VEGF-C in cancerous tissues and paracancerous tissues was compared.The expression of PGK1 and VEGF-C in cancerous tissues of endometrial carcinoma patients with different pathological features was compared.The Kaplan-Meier survival curves was adopted to analyze the prognosis of patients with different PGK1 and VEGF-C expression.Results The proportions of patients with high expression of PGK1 and VEGF-C positivity in cancerous tissues were significantly higher than those in paracancerous tissues(P<0.05).The proportions of low-differentiation,FIGO stagesⅢtoⅣand lymph node metastasis in patients with high PGK1 expression were significantly higher than those in patients with low PGK1 expression(P<0.05),and the proportions of FIGO stagesⅢtoⅣand lymph node metastasis in VEGF-C-positive patients were significantly higher than those in VEGF-C-negative patients(P<0.05).The 3-year survival rate of 106 patients with endometrial carcinoma was 79.25%(84/106).Kaplan-Meier survival results showed that the 3-year survival rates of patients with high PGK1 expression[67.44%(29/43)]were significantly lower than those of patients with low PGK1 expression[87.30%(55/63)],with statistically significant difference(Log-Rankχ^(2)=7.513,P<0.01);the 3-year survival rate of VEGF-C-positive patients[75.00%(60/80)]was significantly lower than that of VEGF-C-negative patients[92.31%(24/26)]with statistically significant difference(Log-Rankχ^(2)=6.527,P<0.01).Co

关 键 词：子宫内膜癌 磷酸甘油酸酯激酶1 血管内皮生长因子-C 病理特征 预后 

分 类 号：R737.33[医药卫生—肿瘤]