TSGF、Tpo-Ab、TSH在分化型甲状腺癌患者中的表达及意义  

Expression and significance of TSGF,Tpo-Ab,TSH in patients with differentiated thyroid cancer

作　　者：贾新琴 李文东 许开利 JIA Xinqin;LI Wendong;XU Kaili(Department of Clinical Laboratory,Changxing People′s Hospital of Chongming District,Shanghai 201913,China;Department of Clinical Laboratory,Shanghai Quyang Hospital,Shanghai 200092,China;Department of Endocrinolgoy,Changxing People′s Hospital of Chongming District,Shanghai 201913,China)

机构地区：[1]上海市崇明区长兴人民医院检验科,上海201913 [2]上海曲阳医院检验科,上海200092 [3]上海市崇明区长兴人民医院内分泌科,上海201913

出　　处：《国际检验医学杂志》2024年第9期1136-1140,共5页International Journal of Laboratory Medicine

摘　　要：目的 探讨肿瘤特异性生长因子(TSGF)、抗甲状腺过氧化物酶抗体(Tpo-Ab)和促甲状腺激素(TSH)在分化型甲状腺癌(DTC)患者中的表达及意义。方法 选取上海曲阳医院2017年8月至2020年8月收治的96例DTC患者,以术中所取得的癌组织作为DTC组,另取其癌旁正常甲状腺组织作为对照组。采用酶联免疫吸附试验(ELISA)检测TSGF、TSH水平,采用荧光磁微粒免疫法检测Tpo-Ab水平,Kaplan-Meier法分析TSGF、Tpo-Ab、TSH水平与DTC患者预后的关系,Cox回归分析影响DTC患者预后的危险因素。结果 与对照组相比,DTC组的TSGF、Tpo-Ab、TSH水平显著升高,差异有统计学意义(P<0.05);肿瘤分期Ⅲ期、发生腺外浸润的DTC患者TSGF、Tpo-Ab、TSH水平显著高于肿瘤分期Ⅰ~Ⅱ期、未发生腺外浸润的DTC患者,差异有统计学意义(P<0.05)。TSGF、Tpo-Ab、TSH高水平组患者2年生存率分别显著低于低水平组,差异有统计学意义(χ^(2)=6.095、6.095、9.524,P=0.014、0.014、0.002)。与生存组相比,死亡组TSGF、Tpo-Ab、TSH水平显著升高,差异有统计学意义(P<0.05)。多因素Cox回归分析显示,肿瘤分期、腺外浸润、TSGF、Tpo-Ab、TSH水平是影响DTC患者预后的危险因素(P<0.05)。结论 DTC组织中TSGF、Tpo-Ab、TSH水平增加,三者水平与DTC患者临床病理特征和预后密切相关。Objective To investigate the expression and significance of tumor specific growth factor(TSGF),anti thyroid peroxidase antibody(Tpo-Ab)and thyroid-stimulating hormone(TSH)in patients with differentiated thyroid cancer(DTC).Methods A total of 96 patients with DTC admitted to Shanghai Quyang Hospital from August 2017 to August 2020 were selected.The cancer tissue obtained during surgery was selected as the DTC group,and the normal thyroid tissue adjacent to the cancer was applied as the control group.Enzyme linked immunosorbent assay(ELISA)was applied to detect TSGF and TSH levels.Fluorescent magnetic particle immunoassay was applied to detect Tpo-Ab level.Kaplan-Meier method was applied to analyze the relationship between TSGF,Tpo-Ab,TSH levels and the prognosis of DTC patients.Cox regression was applied to analyze risk factors affecting the prognosis of DTC patients.Results Compared with the control group,the levels of TSGF,Tpo-Ab,and TSH in the DTC group were obviously increased,and the differences were statistically significant(P<0.05).The levels of TSGF,Tpo-Ab,and TSH in DTC patients with tumor stageⅢand extraglandular infiltration were obviously higher than those in DTC patients with tumor stageⅠ-Ⅱand no extraglandular infiltration,and the differences were statistically significant(P<0.05).The 2-year survival rates of patients with high levels of TSGF,Tpo-Ab,and TSH were obviously lower than those of patients with low levels,and the differences were statistically significant(χ2=6.095,6.095,9.524,P=0.014,0.014,0.002).Compared with the survival group,the levels of TSGF,Tpo-Ab,and TSH in the death group were obviously increased,and the differences were statistically significant(P<0.05).Multivariate Cox regression analysis showed that tumor staging,extraglandular infiltration,TSGF,Tpo-Ab,and TSH levels were risk factors affecting the prognosis of DTC patients(P<0.05).Conclusion The levels of TSGF,Tpo-Ab,and TSH in DTC tissues increase,and their levels are closely related to the clinical pathological charac

关 键 词：肿瘤特异性生长因子 抗过氧化物酶抗体 促甲状腺激素 分化型甲状腺癌 预后 

分 类 号：R730.43[医药卫生—肿瘤] R736.1[医药卫生—临床医学]