Changes in the terminology and diagnostic criteria of non-alcoholic fatty liver disease:Implications and opportunities  

作　　者：Muhammed Mubarak 

机构地区：[1]Javed I.Kazi Department of Histopathology,Sindh Institute of Urology and Transplantation,Karachi 74200,Pakistan

出　　处：《World Journal of Gastrointestinal Pathophysiology》2024年第1期1-8,共8页世界胃肠病理生理学杂志（英文版）（电子版）

摘　　要：Fatty liver disease(FLD)is a highly prevalent pathological liver disorder.It has many and varied etiologies and has heterogeneous clinical course and outcome.Its proper nomenclature and classification have been problematic since its initial recognition.Traditionally,it was divided into two main categories:Alcoholassociated liver disease and nonalcoholic FLD(NAFLD).Among these,the latter condition has been plagued with nomenclature and classification issues.The two main objections to its use have been the use of negative(non-alcoholic)and stigmatizing(fatty)terms in its nomenclature.Numerous attempts were made to address these issues but none achieved universal acceptance.Just recently,NAFLD has received a new nomenclature from an international collaborative effort based on a rigorous scientific methodology.FLD has been renamed steatotic liver disease(SLD),and NAFLD as metabolic dysfunction-associated SLD.Metabolic dysfunction-associated steatohepatitis was chosen as the replacement terminology for non-alcoholic steatohepatitis.This is a significant positive change in the nomenclature and categorization of FLD and will likely have a major impact on research,diagnosis,treatment,and prognosis of the disease in the future.

关 键 词：Fatty liver disease Metabolic syndrome Non-alcoholic fatty liver disease Steatotic liver disease STEATOHEPATITIS 

分 类 号：R575.5[医药卫生—消化系统] R543.5[医药卫生—内科学]