Prevalence and outcome of sarcopenia in non-alcoholic fatty liver disease  

作　　者：Suprabhat Giri Prajna Anirvan Sumaswi Angadi Ankita Singh Anurag Lavekar 

机构地区：[1]Department of Gastroenterology and Hepatology,Kalinga Institute of Medical Sciences,Bhubaneswar 751024,Odisha,India [2]Department of Gastroenterology,Kalinga Gastroenterology Foundation,Cuttack,753001,Odisha,India [3]Department of Gastroenterology,Nizam’s Institute of Medical Sciences,Hyderabad 500082,Telangana,India [4]Department of Gastroenterology,Seth GS Medical College and KEM Hospital,Mumbai 400012,Maharashtra,India [5]Department of Gastroenterology,Sagar Hospital,Bengaluru 560041,Karnataka,India

出　　处：《World Journal of Gastrointestinal Pathophysiology》2024年第1期44-54,共11页世界胃肠病理生理学杂志（英文版）（电子版）

摘　　要：BACKGROUND Nonalcoholic fatty liver disease(NAFLD)includes a spectrum of conditions,progressing from mild steatosis to advanced fibrosis.Sarcopenia,characterized by decreased muscle strength and mass,shares common pathophysiological traits with NAFLD.An association exists between sarcopenia and increased NAFLD prevalence.However,data on the prevalence of sarcopenia in NAFLD and its impact on the outcomes of NAFLD remain inconsistent.AIM To analyze the prevalence and outcomes of sarcopenia in patients with NAFLD.METHODS We conducted a comprehensive search for relevant studies in MEDLINE,Embase,and Scopus from their inception to June 2023.We included studies that focused on patients with NAFLD,reported the prevalence of sarcopenia as the primary outcome,and examined secondary outcomes,such as liver fibrosis and other adverse events.We also used the Newcastle-Ottawa scale for quality assessment.RESULTS Of the 29 studies included,the prevalence of sarcopenia in NAFLD varied widely(1.6%to 63.0%),with 20 studies reporting a prevalence of more than 10.0%.Substantial heterogeneity was noted in the measurement modalities for sarcopenia.Sarcopenia was associated with a higher risk of advanced fibrosis(odd ratio:1.97,95%confidence interval:1.44-2.70).Increased odds were consistently observed in fibrosis assessment through biopsy,NAFLD fibrosis score/body mass index,aspartate aminotransferase to alanine aminotransferase ratio,diabetes(BARD)score,and transient elastography,whereas the fibrosis-4 score showed no such association.Sarcopenia in NAFLD was associated with a higher risk of steatohepatitis,insulin resistance,cardiovascular risks,and mortality.CONCLUSION This systematic review highlights the critical need for standardized diagnostic criteria and measurement methods for sarcopenia in NAFLD patients.The variability in study designs and assessment methods for sarcopenia and liver fibrosis may account for the inconsistent findings.This review demonstrates the multidimensional impact of sarcopenia on NAFLD,indicating its

关 键 词：Non-alcoholic fatty liver disease SARCOPENIA Hepatic fibrosis Low muscle mass Hand grip strength Bioelectric impedance analysis Dual X-ray absorptiometry 

分 类 号：R575.5[医药卫生—消化系统] R575.62[医药卫生—内科学]