Investigating causal links between gastroesophageal reflux disease and essential hypertension  

作　　者：Gowthami Sai Kogilathota Jagirdhar Yatinder Bains Salim Surani 

机构地区：[1]Department of Medicine,Saint Francis Health Science Center,Newark,NJ 07107,United States [2]Department of Gastroenterology,Saint Michaels Medical Center,Newark,NJ 07102,United States [3]Department of Medicine and Pharmacology,Texas A&M University,College Station,TX 77843,United States

出　　处：《World Journal of Clinical Cases》2024年第14期2304-2307,共4页世界临床病例杂志

摘　　要：Gastroesophageal reflux disease(GERD)is a prevalent global health concern with a rising incidence.Various risk factors,including obesity,hiatal hernia,and smo-king,contribute to its development.Recent research suggests associations bet-ween GERD and metabolic syndrome,cardiac diseases,and hypertension(HTN).Mechanisms linking GERD to HTN involve autonomic dysfunction,inflammatory states,and endothelial dysfunction.Furthermore,GERD medications such as pro-ton-pump inhibitors may impact blood pressure regulation.Conversely,antihy-pertensive medications like beta-blockers and calcium channel blockers can exacerbate GERD symptoms.While bidirectional causality exists between GERD and HTN,longitudinal studies are warranted to elucidate the precise relationship.Treatment of GERD,including anti-reflux surgery,may positively influence HTN control.However,the interplay of lifestyle factors,comorbidities,and medications necessitates further investigation to comprehensively understand this relation-ship.In this editorial,we comment on the article published by Wei et al in the recent issue of the World Journal of Clinical Cases.We evaluate their claims on the causal association between GERD and HTN.

关 键 词：Gastroesophageal reflux disease HYPERTENSION Metabolic syndrome Gastro-esophageal reflux disease Hiatal hernia 

分 类 号：R571[医药卫生—消化系统]