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作 者:Ya-Lan Chen Rui-Yao Wang Ling Mei Ran Duan
机构地区:[1]Department of Gastroenterology,The Affiliated Hospital of Hebei University,Baoding 071000,Hebei Province,China [2]Department of Thoracic Surgery,The Affiliated Hospital of Hebei University,Baoding 071000,Hebei Province,China [3]Department of Medical Imageology,The Affiliated Hospital of Hebei University,Baoding 071000,Hebei Province,China
出 处:《World Journal of Clinical Cases》2024年第14期2431-2437,共7页世界临床病例杂志
摘 要:BACKGROUND Cronkhite-Canada syndrome(CCS)is a rare disease of unknown etiology.The optimal treatment for CCS remains unknown.Treatment with corticosteroids is considered the mainstay treatment because of its high efficacy,but the therapeutic strategy for steroid-resistant CCS is not yet established.CASE SUMMARY This is the case of an 81-year-old woman who was diagnosed with CCS.Given her severe diarrhea,nausea,vomiting,and hypoproteinemia,hormone therapy(40 mg/d)was administered,and the symptoms improved within 1 wk.After 3 mo,the patient had no obvious symptoms.The polyps were significantly reduced on review gastroscopy and colonoscopy,thus hormone reduction gradually began.The hormone level was maintained at 10 mg/d after 6 mo.Despite the age of the patient and the side effects of hormones,the patient had no obvious discomfort.However,hormone drugs were discontinued,and mesalazine was administered orally at 3 g/d.The patient's symptoms continued to improve after a follow-up of 5 years.CONCLUSION Corticosteroids and mesalazine are potential treatment options for CCS.
关 键 词:Cronkhite-Canada syndrome Corticosteroids MESALAZINE Gastrointestinal polyposis Case report
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