Rising tide: The global surge of type 2 diabetes in children and adolescents demands action now  

作　　者：Joseph M Pappachan Cornelius James Fernandez Ambika P Ashraf 

机构地区：[1]Department of Endocrinology and Metabolism,Lancashire Teaching Hospitals NHS Trust,Preston PR29HT,United Kingdom [2]Faculty of Science,Manchester Metropolitan University,Manchester M156BH,United Kingdom [3]Faculty of Biology,Medicine&Health,The University of Manchester,Manchester M139PL,United Kingdom [4]Department of Endocrinology&Metabolism,Pilgrim Hospital,United Lincolnshire Hospitals NHS Trust,Boston PE219QS,United Kingdom [5]Division of Pediatric Endocrinology and Diabetes,Department of Pediatrics,University of Alabama at Birmingham,Birmingham,AL 35233,United States

出　　处：《World Journal of Diabetes》2024年第5期797-809,共13页世界糖尿病杂志（英文版）（电子版）

摘　　要：Childhood-onset obesity has emerged as a major public healthcare challenge across the globe,fueled by an obesogenic environment and influenced by both genetic and epigenetic predispositions.This has led to an exponential rise in the incidence of type 2 diabetes mellitus in children and adolescents.The looming wave of diabetes-related complications in early adulthood is anticipated to strain the healthcare budgets in most countries.Unless there is a collective global effort to curb the devastation caused by the situation,the impact is poised to be pro-found.A multifaceted research effort,governmental legislation,and effective social action are crucial in attaining this goal.This article delves into the current epidemiological landscape,explores evidence concerning potential risks and consequences,delves into the pathobiology of childhood obesity,and discusses the latest evidence-based management strategies for diabesity.

关 键 词：Childhood obesity DIABESITY Type 2 diabetes mellitus ADOLESCENCE Cardiovascular disease PHARMACOTHERAPY 

分 类 号：R473.5[医药卫生—护理学]