Psychiatric outcomes in outpatients affected by long COVID:A link between mental health and persistence of olfactory complaint  

作　　者：Victoria Metelkina-Fernandez Louise-Emilie Dumas Clair Vandersteen David Chirio Auriane Gros Arnaud Fernandez Florence Askenazy Valeria Manera 

机构地区：[1]Department of Psychiatry,Nice University Hospital,Nice 06000,France [2]Department of Child and Adolescent Psychiatry,UniversitéCôte d’Azur,Nice 06200,France [3]ENT,Head and Neck Institute,Nice 06100,France [4]Department of Infectiology,Nice University Hospital,Nice 06200,France [5]Department of Orthophony,UniversitéCôte d’Azur,Nice 06100,France [6]Cobtek,UniversitéCôte d’Azur,Nice 06100,France

出　　处：《World Journal of Psychiatry》2024年第4期507-512,共6页世界精神病学杂志

摘　　要：BACKGROUND Anosmia was one of the main symptoms of coronavirus disease 2019(COVID-19).A psychiatric history(i.e.,depression)may be an independent contributor to the risk of COVID-19 diagnosis,and COVID-19 survivors appear to have an increased risk of neuropsychiatric sequelae(bidirectional association).AIM To compare the rate of psychiatric disorder among post-COVID patients without anosmia vs patients with persistent olfactory complaints.METHODS We conducted a prospective case control study from March 2020 to May 2021.Patients recruited at the ENT department of Nice University Hospital had a subjective olfactory complaint(visual analogue scale)for over 6 wk and a molecular or CT-proven severe acute respiratory syndrome coronavirus 2 diagnosis confirmed by serology.Post-COVID patients without persistent olfactory disorders were recruited at the university hospital infectiology department.Psychiatric medical histories were collected by a psychiatrist during the assessments.RESULTS Thirty-four patients with post-COVID-19 olfactory complaints were included in the first group of the study.Fifty percent of the patients were female(n=17).The group’s mean age was 40.5±12.9 years.The control group included 32 participants,of which 34.4%were female(n=11),and had a mean age of 61.2±12.2 years.The rate of psychiatric disorder among post-COVID patients with olfactory complaints was significatively higher(41.7%)than among patients without(18.8%)(χ2=5.9,P=0.015).CONCLUSION The presence of a psychiatric history may constitute a potential risk factor for the development of long COVID due to persistent anosmia.It therefore seems important to establish reinforced health monitoring after a COVID 19 infection in at-risk patients.Further prospective,translational,and collaborative studies are needed to extrapolate these results to the general population.

关 键 词：COVID-19 ANOSMIA PSYCHIATRY Stress NEUROPLASTICITY Psychiatric history 

分 类 号：R395.6[哲学宗教—心理学]