Outcomes of long-acting injectable antipsychotics use in pregnancy:A literature review  

作　　者：Ana V Pejčić Srdjan M Stefanović MilošN Milosavljević Vladimir S Janjić Marko M Folić Nevena D Folić Jovana Z Milosavljević 

机构地区：[1]Department of Pharmacology and Toxicology,Faculty of Medical Sciences,University of Kragujevac,Kragujevac 34000,Serbia [2]Department of Pharmacy,Faculty of Medical Sciences,University of Kragujevac,Kragujevac 34000,Serbia [3]Department of Clinical Pharmacology,University Clinical Center Kragujevac,Kragujevac 34000,Serbia [4]Department of Psychiatry,Faculty of Medical Sciences,University of Kragujevac,Kragujevac 34000,Serbia [5]Clinic for Psychiatry,University Clinical Center Kragujevac,Kragujevac 34000,Serbia [6]Center for Pharmaceutical and Pharmacological Research,Faculty of Medical Sciences,University of Kragujevac,Kragujevac 34000,Serbia [7]Department of Pediatrics,Faculty of Medical Sciences,University of Kragujevac,Kragujevac 34000,Serbia [8]Pediatric Clinic,University Clinical Center Kragujevac,Kragujevac 34000,Serbia [9]Department of Anatomy,Faculty of Medical Sciences,University of Kragujevac,Kragujevac 34000,Serbia

出　　处：《World Journal of Psychiatry》2024年第4期582-599,共18页世界精神病学杂志

摘　　要：BACKGROUND Women with a history of serious psychotic disorders are at increased risk of disease relapse during pregnancy.Long-acting injectable(LAI)antipsychotics have been widely used to improve adherence and prevent relapse in patients with various severe psychotic disorders,but there is a lack of high-quality data from previous research on the safety of LAI antipsychotics during pregnancy.AIM To summarize relevant data on maternal,pregnancy,neonatal,and developmental outcomes from published cases of LAI antipsychotic use in pregnancy.METHODS A literature search was performed through November 11,2023,using three online databases:PubMed/MEDLINE,Scopus,and Web of Science.Case reports or case series that reported information about the outcomes of pregnancy in women who used LAI antipsychotics at any point in pregnancy,with available full texts,were included.Descriptive statistics,narrative summation,and tabulation of the extracted data were performed.RESULTS A total of 19 publications satisfied the inclusion criteria:3 case series,15 case reports,and 1 conference abstract.They reported the outcomes of LAI antipsychotic use in 74 women and 77 pregnancies.The use of secondgeneration LAI antipsychotics was reported in the majority(n=47;61.0%)of pregnancies.First-generation LAI antipsychotics were administered during 30 pregnancies(39.0%).Most of the women(approximately 64%)had either satisfactory control of symptoms or no information about relapse,while approximately 12%of them had developed gestational diabetes mellitus.A minority of cases reported adverse outcomes such as stillbirth,spontaneous abortion,preterm birth,low birth weight,congenital anomalies,and neurological manifestations in newborns.However,there were no reports of negative long-term developmental outcomes.CONCLUSION Currently available data seem reassuring,but further well-designed studies are required to properly evaluate the risks and benefits of LAI antipsychotic use during pregnancy.

关 键 词：Antipsychotic agents Long-acting injectable PREGNANCY OUTCOME Review 

分 类 号：R749.61[医药卫生—神经病学与精神病学]