Small-diameter acellular porcine corneal stroma for peripheral corneal ulceration treatment  

作　　者：Tian Liang Xia Wang Jie Wu Yan Cheng 

机构地区：[1]Department of Ophthalmology,Xi’an No.1 Hospital,Xi’an 710002,Shaanxi Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第5期831-837,共7页国际眼科杂志（英文版）

基　　金：Key R&D Plan of Shaanxi Province(No.2021SF-331).

摘　　要：AIM:To evaluate the clinical efficacy of small-diameter acellular porcine corneal stroma(SAPS)for the treatment of peripheral corneal ulceration(PCU).METHODS:This retrospective clinical study included 18 patients(18 eyes)with PCU between April 2018 and December 2020.All patients had PCU and underwent lamellar keratoplasty with SAPS.Observation indicators included preoperative and postoperative best-corrected visual acuity(BCVA)and transparency of SAPS.The infection control rate in the surgical eye-lesion area was also calculated.RESULTS:Eighteen patients underwent lamellar keratoplasty with SAPS to treat PCU.None of the patients experienced rejection after 6mo(18/18)and 12mo(16/16)of follow-up.The BCVA(0.47±0.30)at the 6mo followup after operation was significantly improved compared with the baseline(0.99±0.80),and the difference was statistically significant(Z=-3.415,P<0.05).The BCVA at the 12mo follow-up after operation was not statistically significant compared to the 6mo(Z=0,P=1).With time,the SAPS graft gradually became transparent.At the 6mo(18/18)and 12mo(16/16)follow-up,none of the patients had recurrent corneal infection.CONCLUSION:SAPS is clinically effective in the treatment of PCU,improving the patient’s BCVA and reducing the incidence of rejection after keratoplasty.

关 键 词：acellular porcine corneal stroma lamellar keratoplasty infectious corneal ulcer 

分 类 号：R772.2[医药卫生—眼科]