Repeatability,interocular correlation and agreement of optic nerve head vessel density in healthy eyes:a sweptsource optical coherence tomographic angiography study  

作　　者：Dan-Qi Fang Da-Wei Yang Xiao-Ting Mai Carol Y Cheung Hao-Yu Chen 

机构地区：[1]Joint Shantou International Eye Center,Shantou University&the Chinese University of Hong Kong,Shantou 515041,Guangdong Province,China [2]Department of Ophthalmology and Visual Sciences,Chinese University of Hong Kong,Hong Kong 999077,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第5期896-903,共8页国际眼科杂志（英文版）

基　　金：Natural Science Foundation of Guangdong Province(No.2018A0303130306);Shantou Science and Technology Program(No.190917085269835,No.200629165261641).

摘　　要：AIM:To assess the repeatability,interocular correlation,and agreement of quantitative swept-source optical coherence tomography angiography(OCTA)optic nerve head(ONH)parameters in healthy subjects.METHODS:Thir ty-three healthy subjects were enrolled.The ONH of both eyes were imaged four times by a swept-source-OCTA using a 3 mm×3 mm scanning protocol.Images of the radial peripapillary capillary were analyzed by a customized Matlab program,and the vessel density,fractal dimension,and vessel diameter index were measured.The repeatability of the four scans was determined by the intraclass correlation coefficient(ICC).The most well-centered optic disc from the four repeated scans was then selected for the interocular correlation and agreement analysis using the Pearson correlation coefficient,ICC and Bland-Altman plots.RESULTS:All swept-source-OCTA ONH parameters exhibited certain repeatability,with ICC>0.760 and coefficient of variation(CoV)≤7.301%.The obvious interocular correlation was observed for papillary vessel density(ICC=0.857),vessel diameter index(ICC=0.857)and fractal dimension(ICC=0.906),while circumpapillary vessel density exhibited moderate interocular correlation(ICC=0.687).Bland-Altman plots revealed an agreement range of-5.26%to 6.21%for circumpapillary vessel density.CONCLUSION:OCTA ONH parameters demonstrate good repeatability in healthy subjects.The interocular correlations of papillary vessel density,fractal dimension and vessel diameter index are high,but the correlation for circumpapillary vessel density is moderate.

关 键 词：interocular correlation REPEATABILITY optic nerve head optical coherence tomography angiography vessel density 

分 类 号：R774.5[医药卫生—眼科]