Corneal collagen cross-linking in patients with keratoconus from the Dresden protocol to customized solutions:theoretical basis  

作　　者：Ciro Caruso Luca D’Andrea Mario Troisi Michele Rinaldi Raffaele Piscopo Salvatore Troisi Ciro Costagliola 

机构地区：[1]Corneal Transplant Center,Pellegrini Hospital,Via Portamedina alla Pignasecca 41,Napoli 80127,Italy [2]Eye Clinic,Department of Neurosciences,Reproductive and Odontostomatological Sciences,University of Naples Federico II,Naples 80131,Italy [3]Public Health Department,University of Naples Federico II,Naples 80131,Italy [4]Salerno Hospital University,Ophthalmologic Unit,Baronissi,Campania 84131,Italy

出　　处：《International Journal of Ophthalmology(English edition)》2024年第5期951-962,共12页国际眼科杂志（英文版）

摘　　要：Keratoconus is an ectatic condition characterized by gradual corneal thinning,corneal protrusion,progressive irregular astigmatism,corneal fibrosis,and visual impairment.The therapeutic options regarding improvement of visual function include glasses or soft contact lenses correction for initial stages,gas-permeable rigid contact lenses,scleral lenses,implantation of intrastromal corneal ring or corneal transplants for most advanced stages.In keratoconus cases showing disease progression corneal collagen crosslinking(CXL)has been proven to be an effective,minimally invasive and safe procedure.CXL consists of a photochemical reaction of corneal collagen by riboflavin stimulation with ultraviolet A radiation,resulting in stromal crosslinks formation.The aim of this review is to carry out an examination of CXL methods based on theoretical basis and mathematical models,from the original Dresden protocol to the most recent developments in the technique,reporting the changes proposed in the last 15y and examining the advantages and disadvantages of the various treatment protocols.Finally,the limits of non-standardized methods and the perspectives offered by a customization of the treatment are highlighted.

关 键 词：corneal collagen cross linking KERATOCONUS custom fast protocol Dresden protocol lambert-beer law Bunsen-roscoe law 

分 类 号：R772.2[医药卫生—眼科]