先天性黑素细胞痣的发病机制及诊疗策略  

The pathogenesis and therapeutic strategies for congenital melanocytic nevi

作　　者：李东东 王斌[1] LI Dongdong;WANG Bin(Department of Plastic and Reconstructive Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院整复外科,上海市200011

出　　处：《组织工程与重建外科》2024年第2期254-259,共6页Journal of Tissue Engineering and Reconstructive Surgery

基　　金：国家重点研发计划(2022YFC2703700,2022YFC2703704);上海市科学技术委员会临床医学研究中心项目(22MC1940300);上海交通大学医学院附属第九人民医院先天性肢体畸形生物样本库建设项目(YBKB202108)、罕见病注册登记项目(JYHJB202205)。

摘　　要：先天性黑素细胞痣(Congenital melanocytic nevi,CMN)是一种常见的皮肤发育异常,可发生于人体任何有黑素细胞存在的部位。其发生与体细胞突变密切相关,受多种信号通路调控,临床表现多样。手术切除、扩张器应用仍是治疗CMN的主要方式,光电治疗是消除色素、清除卫星灶的有力手段。靶向、免疫治疗正成为治疗先天性黑色素巨痣的新方向。Congenital melanocytic nevus is a common skin developmental abnormality that can occur in any part of the body where melanocytes are present.Its occurrence is closely related to somatic cell mutations,regulated by multiple signaling pathways,and has diverse clinical manifestations.Surgical excision and dilator are still the main treatments for CMN,and laser therapy is a powerful mean to eliminate pigmentation and remove satellite lesions.Targeted therapy and immunotherapy are becoming a new direction for the treatment of congenital melanin giant nevi.

关 键 词：先天性黑素细胞痣 发病机制 体细胞突变 靶向治疗 

分 类 号：R758.51[医药卫生—皮肤病学与性病学]