内毒素性实热证猕猴视网膜血管直径变化研究  

Study of retinal vessel diameter changes in rhesus monkeys with endotoxin-inducedexcess heat syndrome

作　　者：吴艳霞 宋姗姗 路雪婧 Wu Yanxia;Song Shanshan;Lu Xuejing(Eye School of Chengdu University of TCM,Chengdu,Sichuan,610075;School of Chinese Classics,Chengdu University of TCM,Chengdu,Sichuan,610075;Ineye Hospital of Chengdu University of TCM,Chengdu,Sichuan,610084;Key Laboratory of Sichuan Province Ophthalmopathy Prevention&Cure and Visual Function Protection,Chengdu,Sichuan,610075;Retinal Image Technology and Chronic Vascular Disease Prevention&Control and Collaborative Innovation Center,Chengdu,Sichuan,610075)

机构地区：[1]成都中医药大学眼科学院,四川成都610075 [2]成都中医药大学国学院,四川成都610075 [3]成都中医大银海眼科医院,四川成都610084 [4]中医药眼病防治与视功能保护四川省重点实验室,四川成都610075 [5]视网膜图像技术与慢性血管性疾病防治协同创新中心,四川成都610075

出　　处：《中医眼耳鼻喉杂志》2024年第2期63-66,共4页Journal of Chinese Ophthalmology and Otorhinolaryngology

基　　金：国家重大科学仪器专项MSFRI在中医理论研究中的应用(2013YQ49085904);成都中医药大学杏林学者学科人才研究推广计划项目(XKTD2022009);中国中医科学院科技创新工程部传承与传播部(XJ2023001701)。

摘　　要：目的探索内毒素性实热证猕猴视网膜血管直径的变化。方法本研究采用内毒素肌肉注射建立猕猴实热证模型;造模成功后,利用Oxymap设备采集眼底图片,并对视网膜动、静脉直径进行分析;实热证组和对照组的直径大小变化数据分析采用独立样本t检验。结果内毒素性实热证猕猴模型造模成功。实热证组与对照组相比静脉、鼻侧动脉直径明显缩小(P<0.05);而颞上动脉和颞下动脉直径虽有不同程度缩小(P>0.05)。结论内毒素性实热证猕猴的视网膜血管直径会呈现不同程度的收缩。视网膜血管直径具有成为中医证候定量指标的潜力。Objective To explore the changes of retinal vessel diameter of rhesus monkeys with endotoxin-induced excess heat syndrome.Methods In this study,we established an experimental pyrexia macaque model by intramuscularly injecting endotoxin.After successful modeling,Oxymap was used to capture fundus images of the macaques,and subsequent analysis focused on assessing retinal artery and vein diameters.An independent samples t-test was employed to analyze the variations in diameter between the experimental and control groups.Results The experimental group exhibited a significant decrease in the diameter of both venous and nasal arteries compared to the control group(P<0.05).However,varying degrees of reduction were observed in the diameter of the superior temporal artery and inferior temporal artery(P>0.05).Conclusion In the state of endotoxic fever,rhesus monkeys exhibit varying degrees of constriction in their retinal arteries and veins,suggesting the potential utility of retinal vessel diameter as a quantitative indicator for syndromes in traditional Chinese medicine.

关 键 词：中医证候模型 猕猴 视网膜血管直径 内毒素 

分 类 号：R77[医药卫生—眼科]