CD7在儿童急性髓细胞性白血病中表达的临床意义  

The clinical significance of CD7 expression in children acute myeloid leukemia

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作  者:李争 朱洁 冯丹 梁昌达[1] LI Zheng;ZHU Jie;FENG Dan;LIANG Changda(Department of Hematology and Oncology,Jiangxi Province Children’s Hospital,Nanchang 330006,Jiangxi,China;Department of Nephrology,Jiangxi Province Children’s Hospital,Nanchang 330006,Jiangxi,China;Department of General Surgery,Jiangxi Province Children’s Hospital,Nanchang 330006,Jiangxi,China)

机构地区:[1]江西省儿童医院血液科,江西南昌330006 [2]江西省儿童医院肾内科,江西南昌330006 [3]江西省儿童医院普外科,江西南昌330006

出  处:《中国现代医生》2024年第12期28-31,共4页China Modern Doctor

基  金:江西省卫生健康委科技计划项目(202130874)。

摘  要:目的探讨CD7在儿童急性髓细胞性白血病(acute myeloid leukemia,AML)中表达的临床意义。方法回顾性分析2016年10月至2020年12月江西省儿童医院收治的60例AML患儿资料,根据免疫分型结果分为CD7阳性(CD7^(+))组和CD7阴性(CD7^(-))组,对比两组患儿的临床特征、免疫表型及治疗效果。结果60例AML患儿中,CD7^(+)18例,阳性率为30.00%;以M2及M5为主,其中M2的表达率为55.56%,高于其他亚型。CD7^(+)组患儿的白细胞计数及骨髓原始粒细胞计数显著高于CD7^(-)组(P<0.05),而两组患儿的血小板计数、血红蛋白、乳酸脱氢酶及肌酐等实验室指标均相近(P>0.05)。患儿均接受标准诱导化疗方案治疗1个疗程后,CD7^(+)组的完全缓解率低于CD7^(-)组(P<0.05)。两组患儿1年和2年的总生存率及无病生存率均相近(P>0.05)。结论与CD7^(-)患儿比较,CD7^(+)患儿外周白细胞计数和骨髓原始细胞计数均显著增高,且第1疗程的完全缓解率显著降低。CD7抗原表达对AML患儿的不良预后具有显著的预测价值,可能为AML患儿的治疗策略提供新的思路,并为进一步探索CD7在AML发展中的作用机制奠定基础。Objective To investigate the clinical significance of CD7 expression in childhood acute myeloid leukemia(AML).Methods A retrospective analysis was performed on 60 children with AML admitted to Jiangxi Province Children’s Hospital from October 2016 to December 2020.According to the results of immunophenotyping,the children were divided into CD7 positive(CD7^(+))group and CD7 negative(CD7^(-))group.The clinical characteristics,immunophenotype and treatment effect of the two groups were compared.Results Among 60 children with AML,18 cases were CD7^(+),and the positive rate was 30.00%,mainly M2 and M5,the expression rate of M2 was 55.56%,which was higher than that of other subtypes.The CD7^(+)group had significantly higher white blood cell count and bone marrow blast granulocyte count than the CD7^(-)group(P<0.05).There were no significant differences in platelet count,hemoglobin,lactate dehydrogenase,creatinine and other laboratory indicators between the two groups(P>0.05).After 1 course of standard induction chemotherapy,the CD7^(+)group had a significantly lower complete remission rate than the CD7^(-)group(P<0.05).There was no statistically significant difference(P>0.05)in the overall survival rate and disease free survival rate between the two groups of patients at 1 year and 2 years.Conclusion Compared with CD7^(-)children,the peripheral white blood cell count and bone marrow blast cell count of CD7^(+)children were significantly higher,and the complete remission rate of induction chemotherapy was significantly lower.The expression of CD7 antigen has a significant predictive value for the poor prognosis of children with AML,which may provide new ideas for the treatment strategy of children with AML,and lay the foundation for further exploring the mechanism of CD7 in the development of AML.

关 键 词:CD7 儿童 急性髓细胞性白血病 临床意义 

分 类 号:R725.5[医药卫生—儿科] R733.7[医药卫生—临床医学]

 

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