Albumin–bilirubin grade as a predictor of survival in hepatocellular carcinoma patients with thrombocytopenia  

作　　者：Zhong-Ran Man Xuan-Kun Gong Kang-Lin Qu Qing Pang Bin-Quan Wu 

机构地区：[1]Department of Hepatobiliary Surgery,The First Affiliated Hospital of Bengbu Medical College,Bengbu 233000,Anhui Province,China [2]Department of Hepatobiliary Surgery,Anhui No.2 Provincial People’s Hospital,Hefei 230041,Anhui Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2024年第5期1763-1772,共10页世界胃肠肿瘤学杂志（英文版）（电子版）

基　　金：Supported by Key Projects of Natural Science Foundation of Bengbu Medical College,No.2021byzd050;Science and Technological Fund of Anhui Province for Outstanding Youth,No.2008085J37.

摘　　要：BACKGROUND The models for assessing liver function,mainly the Child–Pugh(CP),albuminbilirubin(ALBI),and platelet–ALBI(PALBI)classifications,have been validated for use in estimating the prognosis of hepatocellular carcinoma(HCC)patients.However,thrombocytopenia is a common finding and may influence the prognostic value of the three models in HCC.AIM To investigate and compare the prognostic performance of the above three models in thrombocytopenic HCC patients.METHODS A total of 135 patients with thrombocytopenic HCC who underwent radical surgery were retrospectively analyzed.Preoperative scores on the CP,ALBI and PALBI classifications were estimated accordingly.Kaplan–Meier curves with logrank tests and Cox regression models were used to explore the significant factors associated with overall survival(OS)and recurrence-free survival(RFS).RESULTS The preoperative platelet counts were significantly different among the CP,ALBI and PALBI groups.After a median follow-up of 28 mo,39.3%(53/135)of the patients experienced postoperative recurrence,and 36.3%(49/135)died.Univariate analysis suggested thatα-fetoprotein levels,tumor size,vascular invasion,and ALBI grade were significant predictors of OS and RFS.According to the multivariate Cox regression model,ALBI was identified as an independent prognostic factor.However,CP and PALBI grades were not statistically significant prognostic indicators.CONCLUSION The ALBI grade,rather than CP or PALBI grade,is a significant prognostic indicator for thrombocytopenic HCC patients.

关 键 词：Hepatocellular carcinoma THROMBOCYTOPENIA CHILD-PUGH Albumin-bilirubin Platelet-albumin-bilirubin 

分 类 号：R735.7[医药卫生—肿瘤]