术前血清碱性磷酸酶、骨桥蛋白与基底节区脑出血患者神经内镜清除术预后的关系  

Relationship Between Preoperative Serum Alkaline Phosphatase,Osteopontin and the Prognosis of Neuroendoscopic Clearance Surgery in Patients with Basal Ganglia Hemorrhage

作　　者：郭士琨[1] 刘永生[1] 李想[1] GUO Shikun;LIU Yongsheng;LI Xiang(Department of Neurosurgery,the First People’s Hospital of Shangqiu,Shangqiu 476100,China)

机构地区：[1]商丘市第一人民医院神外三科,河南商丘476100

出　　处：《河南医学研究》2024年第9期1633-1636,共4页Henan Medical Research

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20191493)。

摘　　要：目的分析术前血清碱性磷酸酶(ALP)与骨桥蛋白(OPN)与基底节区脑出血患者神经内镜清除术预后的关系,评估其对患者预后的预测价值。方法回顾性采集2019年1月至2023年6月于商丘市第一人民医院完成神经内镜下微创血肿清除术治疗的65例基底节区脑出血患者的资料。记录研究所需实验室指标结果数据,包括术前及术后血清ALP、OPN水平,统计术后1个月患者预后情况,分析脑出血患者术前血清ALP、OPN与预后的关系。结果65例基底节区脑出血患者预后不良14例,占比21.54%。术前及术后,预后不良组患者血清ALP、OPN高于预后良好组(P<0.05)。经过点二列相关性分析,术前血清ALP、OPN与脑出血患者预后不良呈正相关关系(r>0,P<0.05)。绘制受试者工作特征(ROC)曲线,结果显示,术前血清ALP、OPN预测脑出血患者预后不良的曲线下面积(AUC)均>0.70,联合预测的AUC>0.80,联合预测价值更高。结论基底节区脑出血患者神经内镜清除术前ALP、OPN越高,预后不良的可能性越大,术前ALP、OPN可以作为基底节区脑出血患者神经内镜清除术后预后不良的有效预测指标。Objective To analyze the relationship between preoperative serum alkaline phosphatase(ALP)and osteopontin(OPN)and the prognosis of patients with basal ganglia hemorrhage treated with neuroendoscopic clearance surgery,and to evaluate its predictive value for patient prognosis.Methods A retrospective study was conducted to collect data from 65 patients with basal ganglia hemorrhage who underwent minimally invasive hematoma removal surgery under neuroendoscopy at the First People’s Hospital of Shangqiu from January 2019 to June 2023.The results of laboratory indicators required for the study were recorded,including preoperative and postoperative serum ALP and OPN levels.The prognosis of patients 1 month after operation was statistically analyzed,and the relationship between preoperative serum ALP and OPN and prognosis in patients with cerebral hemorrhage was analyzed.Results Among the 65 patients with basal ganglia hemorrhage,14 had poor prognosis,accounting for 21.54%.Before and after operation,serum ALP and OPN in the poor prognosis group were higher than those in the good prognosis group(P<0.05).After point two column correlation analysis,preoperative serum ALP and OPN were positively correlated with poor prognosis in patients with cerebral hemorrhage(r>0,P<0.05).The results of drawing receiver operating characteristic(ROC)curve showed that the area under the curve(AUC)of preoperative serum ALP and OPN predicting poor prognosis in patients with cerebral hemorrhage was greater than 0.70,and the AUC of combined prediction was greater than 0.80,indicating higher combined predictive value.Conclusion The higher the preoperative ALP and OPN levels in patients with basal ganglia hemorrhage undergoing endoscopic clearance surgery,the greater the likelihood of poor prognosis after treatment.Preoperative ALP and OPN levels can be effective predictors of poor prognosis in patients with basal ganglia hemorrhage undergoing endoscopic clearance surgery.

关 键 词：脑出血 基底节区 微创血肿清除术 碱性磷酸酶 骨桥蛋白 预后 

分 类 号：R743.34[医药卫生—神经病学与精神病学]